| Sainte-Pexine | |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason de Sainte-Pexine.svg |
| Arrondissement: | Fontenay-le-Comte |
| Canton: | Mareuil-sur-Lay-Dissais |
| Insee: | 85261 |
| Postal Code: | 85320 |
| Mayor: | James Gandrieau[1] |
| Term: | 2020 - 2026 |
| Coordinates: | 46.5619°N -1.1381°W |
| Elevation Min M: | 7 |
| Elevation Max M: | 68 |
| Area Km2: | 15.76 |
Sainte-Pexine (in French pronounced as /sɛ̃t pɛksin/) is a commune in the Vendée department in the Pays de la Loire region in western France.
The river Lay flows southwestward through the northern part of the commune and forms part of its western border; the river Smagne, a tributary of the Lay, forms most of the commune's southern border.