| Sainte-Hermine | |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason ville fr Sainte-Hermine (Vendée).svg |
| Arrondissement: | Fontenay-le-Comte |
| Canton: | La Châtaigneraie |
| Insee: | 85223 |
| Postal Code: | 85210 |
| Mayor: | Philippe Barré[1] |
| Term: | 2020 - 2026 |
| Coordinates: | 46.5569°N -1.0544°W |
| Elevation Min M: | 12 |
| Elevation Max M: | 83 |
| Area Km2: | 34.47 |
Sainte-Hermine (in French pronounced as /sɛ̃t ɛʁmin/) is a commune in the Vendée department in the Pays de la Loire region in western France.
The river Smagne flows southwestward through the commune and crosses the town. The river Lay forms most of the commune's northern border.