| Sainte-Gemme | |
| Commune Status: | Commune |
| Arrondissement: | Le Blanc |
| Canton: | Le Blanc |
| Insee: | 36193 |
| Postal Code: | 36500 |
| Mayor: | Jean-Louis Marcq[1] |
| Term: | 2020 - 2026 |
| Intercommunality: | Cœur de Brenne |
| Coordinates: | 46.8531°N 1.34°W |
| Elevation M: | 85 |
| Elevation Min M: | 94 |
| Elevation Max M: | 138 |
| Area Km2: | 32.5 |
Sainte-Gemme (in French pronounced as /sɛ̃t ʒɛm/) is a commune in the Indre department in central France.
The commune is located in the parc naturel régional de la Brenne.