| Sainte-Colombe | |
| Commune Status: | Commune |
| Arrondissement: | Gap |
| Canton: | Serres |
| Insee: | 05135 |
| Postal Code: | 05700 |
| Mayor: | Jean-Pierre Roux[1] |
| Term: | 2020 - 2026 |
| Coordinates: | 44.2856°N 5.6694°W |
| Elevation M: | 920 |
| Elevation Min M: | 715 |
| Elevation Max M: | 1360 |
| Area Km2: | 17.18 |
Sainte-Colombe (in French pronounced as /sɛ̃t kɔlɔ̃b/; Vivaro-Alpine: Santa Colomba) is a commune in the Hautes-Alpes department in southeastern France. It is surrounded by mountains.