| Sainte-Colombe | |
| Commune Status: | Commune |
| Arrondissement: | Libourne |
| Canton: | Les Coteaux de Dordogne |
| Insee: | 33390 |
| Postal Code: | 33350 |
| Mayor: | Daniel Thibeau[1] |
| Term: | 2020 - 2026 |
| Intercommunality: | Castillon-Pujols |
| Coordinates: | 44.88°N -0.0603°W |
| Elevation M: | 88 |
| Elevation Min M: | 24 |
| Elevation Max M: | 96 |
| Area Km2: | 4.06 |
Sainte-Colombe (pronounced as /fr/; Languedocien: Senta Coloma) is a commune in the Gironde department in Nouvelle-Aquitaine in southwestern France.