| Sainte-Colombe | |
| Native Name: | (Gallo) |
| Commune Status: | Commune |
| Coordinates: | 47.8886°N -1.455°W |
| Insee: | 35262 |
| Postal Code: | 35134 |
| Arrondissement: | Fougères-Vitré |
| Canton: | La Guerche-de-Bretagne |
| Mayor: | Julien Richard[1] |
| Term: | 2022 - 2026 |
| Intercommunality: | Roche-aux-Fées |
| Elevation Min M: | 47 |
| Elevation Max M: | 106 |
| Area Km2: | 7.58 |
Sainte-Colombe (in French pronounced as /sɛ̃t kɔlɔ̃b/; Gallo: Saentt-Cólonbb-an-la-Méy, Breton: Santez-Koulm) is a commune in the Ille-et-Vilaine department in Brittany in northwestern France.
Inhabitants of Sainte-Colombe are called colombins in French.