| Sainte-Colombe | |
| Commune Status: | Commune |
| Coordinates: | 46.8794°N 6.2681°W |
| Insee: | 25515 |
| Postal Code: | 25300 |
| Arrondissement: | Pontarlier |
| Canton: | Pontarlier |
| Mayor: | Lionel Malfroy[1] |
| Term: | 2020 - 2026 |
| Elevation Min M: | 809 |
| Elevation Max M: | 1024 |
| Area Km2: | 10.49 |
Sainte-Colombe (in French pronounced as /sɛ̃t kɔlɔ̃b/) is a commune in the Doubs department in the Bourgogne-Franche-Comté region in eastern France.
The commune lies 7km (04miles) northeast of Pontarlier in the valley of the Drugeon.
The commune has a railway station,, on the Frasne–Les Verrières line.