| Saint-Sernin-sur-Rance | |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason Saint-Sernin-sur-Rance.svg |
| Arrondissement: | Millau |
| Canton: | Causses-Rougiers |
| Insee: | 12248 |
| Postal Code: | 12380 |
| Mayor: | Patrick Roques [1] |
| Term: | 2022 - 2026 |
| Coordinates: | 43.885°N 2.6042°W |
| Elevation M: | 290 |
| Elevation Min M: | 288 |
| Elevation Max M: | 662 |
| Area Km2: | 11.14 |
Saint-Sernin-sur-Rance (pronounced as /fr/, literally Saint-Sernin on Rance; oc|Sent Sarnin) is a commune in the Aveyron department in southern France.