| Saint-Sernin | |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason ville fr Saint-Sernin (Lot-et-Garonne).svg |
| Arrondissement: | Marmande |
| Canton: | Les Coteaux de Guyenne |
| Insee: | 47278 |
| Postal Code: | 47120 |
| Mayor: | Pierre Clament[1] |
| Term: | 2020 - 2026 |
| Intercommunality: | Pays de Duras |
| Coordinates: | 44.7119°N 0.2394°W |
| Elevation M: | 120 |
| Elevation Min M: | 42 |
| Elevation Max M: | 127 |
| Area Km2: | 21.07 |
Saint-Sernin (in French pronounced as /sɛ̃ sɛʁnɛ̃/; Occitan (post 1500);: Sent Sarnin de Duràs) is a commune in the Lot-et-Garonne department in south-western France.[2]