| Saint-Seine | |
| Commune Status: | Commune |
| Coordinates: | 46.7347°N 3.8247°W |
| Insee: | 58268 |
| Postal Code: | 58250 |
| Arrondissement: | Château-Chinon (Ville) |
| Canton: | Luzy |
| Intercommunality: | Bazois Loire Morvan |
| Mayor: | Serge Sauvaget[1] |
| Term: | 2020 - 2026 |
| Elevation Min M: | 220 |
| Elevation Max M: | 321 |
| Area Km2: | 17.73 |
Saint-Seine (in French pronounced as /sɛ̃ sɛn/) is a commune in the Nièvre department in central France.[2]