| Saint-Rustice | |
| Commune Status: | Commune |
| Arrondissement: | Toulouse |
| Canton: | Villemur-sur-Tarn |
| Insee: | 31515 |
| Postal Code: | 31620 |
| Mayor: | Edmond Aussel[1] |
| Term: | 2020 - 2026 |
| Coordinates: | 43.8064°N 1.3286°W |
| Elevation M: | 108 |
| Elevation Min M: | 107 |
| Elevation Max M: | 217 |
| Area Km2: | 2.36 |
Saint-Rustice (in French pronounced as /sɛ̃ ʁystis/; Occitan (post 1500);: Sent Rostesi) is a commune in the Haute-Garonne department in southwestern France.
Saint-Rustice is famous for its ancient Roman mosaics which were discovered in 1833. The city takes its name from Rusticus, a bishop of Cahors, who was murdered in 630.