| Saint-Marc-sur-Seine | |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason de la ville de Saint-Marc-sur-Seine (Côte-d'Or).svg |
| Arrondissement: | Montbard |
| Canton: | Châtillon-sur-Seine |
| Insee: | 21557 |
| Postal Code: | 21450 |
| Mayor: | Vincent Chauvot[1] |
| Term: | 2020 - 2026 |
| Intercommunality: | Pays Châtillonnais |
| Coordinates: | 47.7017°N 4.6056°W |
| Elevation M: | 272 |
| Elevation Min M: | 265 |
| Elevation Max M: | 411 |
| Area Km2: | 8.4 |
Saint-Marc-sur-Seine (in French pronounced as /sɛ̃ maʁk syʁ sɛn/, literally Saint-Marc on Seine) is a commune in the Côte-d'Or department in eastern France.