| Saint-Lupien | |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason Saint-Lupien.svg |
| Arrondissement: | Nogent-sur-Seine |
| Canton: | Saint-Lyé |
| Insee: | 10348 |
| Postal Code: | 10350 |
| Mayor: | Nicolas Juillet[1] |
| Term: | 2020 - 2026 |
| Intercommunality: | Orvin et Ardusson |
| Coordinates: | 48.3583°N 3.7031°W |
| Elevation M: | 132 |
| Area Km2: | 22.92 |
Saint-Lupien (in French pronounced as /sɛ̃ lypjɛ̃/) is a commune in the Aube department in north-central France.