| Saint-Grégoire | |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason ville fr SaintGregoire (Tarn).svg |
| Arrondissement: | Albi |
| Canton: | Carmaux-1 Le Ségala |
| Insee: | 81253 |
| Postal Code: | 81350 |
| Mayor: | Charles Riva[1] |
| Term: | 2023 - 2026 |
| Intercommunality: | Val 81 |
| Coordinates: | 43.9625°N 2.2622°W |
| Elevation M: | 330 |
| Elevation Min M: | 160 |
| Elevation Max M: | 368 |
| Area Km2: | 12.75 |
Saint-Grégoire (in French pronounced as /sɛ̃ ɡʁeɡwaʁ/; Languedocien: Sent Gorgòri) is a commune in the Tarn department in southern France.