| Saint-Eusèbe | |
| Commune Status: | Commune |
| Insee: | 71412 |
| Postal Code: | 71210 |
| Arrondissement: | Autun |
| Canton: | Blanzy |
| Intercommunality: | CU Creusot Montceau |
| Coordinates: | 46.7142°N 4.4619°W |
| Elevation M: | 320 |
| Elevation Min M: | 284 |
| Elevation Max M: | 401 |
| Area Km2: | 21.21 |
Saint-Eusèbe (in French pronounced as /sɛ̃.t‿øzɛb/) is a commune in the Saône-et-Loire department in the region of Bourgogne-Franche-Comté in eastern France.
The Bourbince forms the commune's western border.