| Saint-Antoine-sur-l'Isle | |
| Commune Status: | Commune |
| Arrondissement: | Libourne |
| Canton: | Le Nord-Libournais |
| Insee: | 33373 |
| Postal Code: | 33660 |
| Mayor: | Pâquerette Peyridieux[1] |
| Term: | 2020 - 2026 |
| Intercommunality: | CA Libournais |
| Coordinates: | 45.0278°N 0.0389°W |
| Elevation M: | 31 |
| Elevation Min M: | 15 |
| Elevation Max M: | 113 |
| Area Km2: | 10.4 |
Saint-Antoine-sur-l'Isle (in French pronounced as /sɛ̃.t‿ɑ̃twan syʁ lil/, literally Saint-Antoine on the Isle; Occitan (post 1500);: Sent Antòni d'Eila) is a commune in the Gironde department in Nouvelle-Aquitaine in southwestern France.