Sadaf Farooqi Explained

Sadaf Farooqi
Birth Name:Ismaa Sadaf Farooqi
Thesis Title:Genetics of severe childhood obesity
Thesis Url:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621345
Thesis Year:2001
Known For:Genetics of obesity
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Ismaa Sadaf Farooqi is a Wellcome Trust Senior Research fellow[1] in Clinical Science, professor of Metabolism and Medicine at the University of Cambridge and a consultant physician at Addenbrooke's Hospital in Cambridge, UK.[2]

Education

Farooqi was educated at the University of Birmingham where she studied medicine, and was awarded a Bachelor of Medicine, Bachelor of Surgery degree in 1993.[3] After working as a pre-registration house officer and senior house officer,[3] she moved into research and was awarded a PhD in 2001 from the University of Cambridge for research on the genetics of severe childhood obesity.[4] [5]

Research

Farooqi's research investigates the genetics of obesity.[6] [7] [8] [9] Using candidate genes found in patients with severe obesity, her research group have identified patients with mutations in genes encoding leptin, the leptin receptor and biological targets of leptin action, such as the Melanocortin 4 receptor (MC4R). Her group have also demonstrated that the central leptin-melanocortin axis plays a critical role in the regulation of human food intake.[10] [11] Research in her laboratory has shown that people who carry variants of the MC4R gene have an increased preference for high fat food (such as certain recipes of chicken korma), but a decreased preference for sugary foods like Eton mess.[4] [12] [13]

Her research has also proven that mutations in the KSR2 gene are associated with insulin resistance[14] and that genetic variation in the fat mass and obesity-associated protein (FTO) is associated with diminished hunger.[15] Her research has been funded by the Wellcome Trust,[1] [16] Addenbrooke's Charitable Trust and the Framework Programmes for Research and Technological Development (FP7) from the European Union.[3]

Awards and honours

Farooqi was elected a Fellow of the Royal Society in 2021.[17] Farooqi was elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2013.[18] Her citation on election reads:

Farooqi was interviewed by Jim Al-Khalili on The Life Scientific, first broadcast on BBC Radio 4 in 2017.[4]

Farooqi was awarded the American Diabetes Association's Outstanding Scientific Achievement Award in 2019.[19]

Notes and References

  1. Web site: https://web.archive.org/web/20170125202551/https://wellcome.ac.uk/what-we-do/directories/senior-research-fellowships-clinical-science-people-funded. 25 January 2017. Senior Research Fellowships in Clinical Science: people we've funded. wellcome.ac.uk. Wellcome Trust. London. Anon. 2016.
  2. Web site: https://web.archive.org/web/20160618080658/http://www.neuroscience.cam.ac.uk/directory/profile.php?isf20. 18 June 2016. Professor Sadaf Farooqi: Cambridge Neuroscience. University of Cambridge. Cambridge. Anon. 2016.
  3. Sadaf Farooqi's
  4. Web site: Sadaf Farooqi on what makes us fat. BBC. London. Jim. Al-Khalili. Jim Al-Khalili. 2017.
  5. PhD. University of Cambridge. Genetics of severe childhood obesity. Ismaa Sadaf. Farooqi. 2001. 894596925.
  6. Gerken . T.. Girard . C. A.. Tung . Y. -C. L.. Webby . C. J.. Saudek . V.. Hewitson . K. S.. Yeo . G. S. H.. McDonough . M. A.. Cunliffe . S.. McNeill. 10.1126/science.1151710 . L. A.. Galvanovskis . J.. Rorsman . P.. Patrik Rorsman. Robins . P.. Prieur . X.. Coll . A. P.. Ma . M.. Jovanovic . Z.. Farooqi . I. S.. Sedgwick . B.. Barroso . I.. Lindahl . T.. Tomas Lindahl. Ponting . C. P.. Chris Ponting. Ashcroft . F. M.. Frances Ashcroft. O'Rahilly . S.. Stephen O'Rahilly. Schofield . C. J.. Christopher J. Schofield. The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase. Science. 318. 5855. 1469–1472. 2007. 17991826. 2668859. 2007Sci...318.1469G.
  7. OʼRahilly. Stephen. Montague. Carl T.. Farooqi. I. Sadaf. Whitehead. Jonathan P.. Soos. Maria A.. Rau. Harald. Wareham. Nicholas J.. Sewter. Ciaran P.. Digby. Janet E.. Mohammed. Shehla N.. Hurst. Jane A.. Cheetham. Christopher H.. Earley. Alison R.. Barnett. Anthony H.. Prins. Johannes B.. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 387. 6636. 1997. 903–908. 9202122. 10.1038/43185. 1997Natur.387..903M. 205032762. free.
  8. Speliotes. Elizabeth K. Willer. Cristen J. Berndt. Sonja I. Monda. Keri L. Thorleifsson. Gudmar. Jackson. Anne U. Allen. Hana Lango. Lindgren. Cecilia M. Luan. Jian'an. Mägi. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature Genetics. 42. 11. 2010. 937–948. 20935630 . 3014648. 10.1038/ng.686.
  9. Farooqi. I. Sadaf. Jebb. Susan A.. Langmack. Gill. Lawrence. Elizabeth. Cheetham. Christopher H.. Prentice. Andrew M.. Hughes. Ieuan A.. McCamish. Mark A.. O'Rahilly. Stephen. Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency. New England Journal of Medicine. 341. 12. 1999. 10486419. 879–884. 10.1056/NEJM199909163411204. free.
  10. Farooqi. I. Sadaf. O'Rahilly. Stephen. Genetics of Obesity in Humans. Endocrine Reviews. 27. 7. 2006. 710–718. 17122358 . 10.1210/er.2006-0040. free.
  11. Web site: James. Gallager. 2013. BBC. Slow metabolism 'obesity excuse' true. London. https://web.archive.org/web/20160206171120/http://www.bbc.co.uk/news/health-24610296. 6 February 2016.
  12. Web site: https://web.archive.org/web/20161108194225/http://www.cam.ac.uk/research/news/chicken-korma-eton-mess-and-a-genetic-variant-provide-clues-to-our-food-choices. 8 November 2016. Chicken korma, Eton mess and a genetic variant provide clues to our food choices. University of Cambridge. Cambridge. Craig. Brierley. 2016.
  13. van der Klaauw. Agatha A.. Keogh. Julia M.. Henning. Elana. Stephenson. Cheryl. Kelway. Sarah. Trowse. Victoria M.. Subramanian. Naresh. O'Rahilly. Stephen. Fletcher. Paul C.. Farooqi. I. Sadaf. Divergent effects of central melanocortin signalling on fat and sucrose preference in humans. Nature Communications. 7. 2016. 13055. 10.1038/ncomms13055. 27701398. 5059464. 2016NatCo...713055V.
  14. Pearce. Laura R.. Atanassova. Neli. Banton. Matthew C.. Bottomley. Bill. van der Klaauw. Agatha A.. Revelli. Jean-Pierre. Hendricks. Audrey. Keogh. Julia M.. Henning. Elana. Doree. Deon. Jeter-Jones. Sabrina. Garg. Sumedha. Bochukova. Elena G.. Bounds. Rebecca. Ashford. Sofie. Gayton. Emma. Hindmarsh. Peter C.. Shield. Julian P.H.. Crowne. Elizabeth. Barford. David. Wareham. Nick J.. O'Rahilly. Stephen. Murphy. Michael P.. Powell. David R.. Barroso. Ines. Farooqi. I. Sadaf. KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation. Cell. 155. 4. 2013. 765–777. 24209692 . 3898740. 10.1016/j.cell.2013.09.058.
  15. Wardle. Jane. Carnell. Susan. Haworth. Claire M. A.. Farooqi. I. Sadaf. O'Rahilly. Stephen. Plomin. Robert. Obesity Associated Genetic Variation in FTO is Associated with Diminished Satiety. The Journal of Clinical Endocrinology and Metabolism. 93. 9. 2008. 3640–3643. 10.1210/jc.2008-0472. 18583465. 13929741. free.
  16. Wellcome Collection
  17. Web site: 2021-05-06. Royal Society elects outstanding new Fellows and Foreign Members. 2021-05-21. The Royal Society. en-gb.
  18. Web site: acmedsci.ac.uk. Professor Sadaf Farooqi FMedSci. London. Anon. 2013. Academy of Medical Sciences. https://web.archive.org/web/20160801012720/http://www.acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/professor-sadaf-farooqi/. 1 August 2016.
  19. Web site: 2019 Outstanding Scientific Achievement Award - Sadaf Farooqi, MB, ChB (Hons), PhD. professional.diabetes.org. 2019-11-14.

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