SYTL1 explained

Synaptotagmin-like protein 1 is a protein that in humans is encoded by the SYTL1 gene.^{[1] [2]}

Interactions

SYTL1 has been shown to interact with RAB27A.^{[3] [4] [5]}

Further reading

• Fukuda M, Mikoshiba K . Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins . Biochemical and Biophysical Research Communications . 281 . 5 . 1226–33 . March 2001 . 11243866 . 10.1006/bbrc.2001.4512 .
• McAdara Berkowitz JK, Catz SD, Johnson JL, Ruedi JM, Thon V, Babior BM . JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase . The Journal of Biological Chemistry . 276 . 22 . 18855–62 . June 2001 . 11278853 . 10.1074/jbc.M011167200 . free .
• Kuroda TS, Fukuda M, Ariga H, Mikoshiba K . The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain . The Journal of Biological Chemistry . 277 . 11 . 9212–8 . March 2002 . 11773082 . 10.1074/jbc.M112414200 . free .
• Strom M, Hume AN, Tarafder AK, Barkagianni E, Seabra MC . A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport . The Journal of Biological Chemistry . 277 . 28 . 25423–30 . July 2002 . 11980908 . 10.1074/jbc.M202574200 . free .
• Fukuda M . Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells . The Journal of Biological Chemistry . 278 . 17 . 15390–6 . April 2003 . 12590134 . 10.1074/jbc.M213090200 . free .
• Johnson JL, Ellis BA, Noack D, Seabra MC, Catz SD . The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase . The Biochemical Journal . 391 . Pt 3 . 699–710 . November 2005 . 16004602 . 1276972 . 10.1042/BJ20050380 .
• Schmid M, Fellermann K, Fritz P, Wiedow O, Stange EF, Wehkamp J . Attenuated induction of epithelial and leukocyte serine antiproteases elafin and secretory leukocyte protease inhibitor in Crohn's disease . Journal of Leukocyte Biology . 81 . 4 . 907–15 . April 2007 . 17200145 . 10.1189/jlb.0906581 . 30032616 .

Notes and References

1. Catz SD, Babior BM, Johnson JL . JFC1 is transcriptionally activated by nuclear factor-kappaB and up-regulated by tumour necrosis factor alpha in prostate carcinoma cells . The Biochemical Journal . 367 . Pt 3 . 791–9 . November 2002 . 12137562 . 1222920 . 10.1042/BJ20020345 .
2. Web site: Entrez Gene: SYTL1 synaptotagmin-like 1.
3. Fukuda M . Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells . The Journal of Biological Chemistry . 278 . 17 . 15390–6 . April 2003 . 12590134 . 10.1074/jbc.M213090200 . free .
4. Strom M, Hume AN, Tarafder AK, Barkagianni E, Seabra MC . A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport . The Journal of Biological Chemistry . 277 . 28 . 25423–30 . July 2002 . 11980908 . 10.1074/jbc.M202574200 . free .
5. Kuroda TS, Fukuda M, Ariga H, Mikoshiba K . The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain . The Journal of Biological Chemistry . 277 . 11 . 9212–8 . March 2002 . 11773082 . 10.1074/jbc.M112414200 . free .