SYT7 explained

Synaptotagmin-7 is a protein that in humans is encoded by the SYT7 gene.^{[1] [2]}

Function

Synaptotagmins, such as SYT7, are calcium-dependent phospholipid-binding proteins known for their role in synaptic exocytosis and neurotransmitter release. Significant expression has also been observed in the prostate and other tissues. See MIM 600782 [supplied by OMIM]^[2]

Interactions

SYT7 has been shown to interact with SYNCRIP.^[3]

Further reading

• Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC . Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins . Nature . 375 . 6532 . 594–9 . June 1995 . 7791877 . 10.1038/375594a0 . 1995Natur.375..594L . 4265549 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . September 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Perin MS . Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin . Biochemistry . 35 . 43 . 13808–16 . October 1996 . 8901523 . 10.1021/bi960853x .
• Craxton M, Goedert M . Alternative splicing of synaptotagmins involving transmembrane exon skipping . FEBS Letters . 460 . 3 . 417–22 . November 1999 . 10556508 . 10.1016/S0014-5793(99)01382-4 . 19207631 . free .
• Walker MG, Volkmuth W, Sprinzak E, Hodgson D, Klingler T . Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes . Genome Research . 9 . 12 . 1198–203 . December 1999 . 10613842 . 310991 . 10.1101/gr.9.12.1198 .
• Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K . SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms . The Journal of Biological Chemistry . 275 . 13 . 9823–31 . March 2000 . 10734137 . 10.1074/jbc.275.13.9823 . free .
• Caler EV, Chakrabarti S, Fowler KT, Rao S, Andrews NW . The Exocytosis-regulatory protein synaptotagmin VII mediates cell invasion by Trypanosoma cruzi . The Journal of Experimental Medicine . 193 . 9 . 1097–104 . May 2001 . 11342594 . 2193425 . 10.1084/jem.193.9.1097 .
• Fukuda M, Ogata Y, Saegusa C, Kanno E, Mikoshiba K . Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human . The Biochemical Journal . 365 . Pt 1 . 173–80 . July 2002 . 12071850 . 1222667 . 10.1042/BJ20011877 .

Notes and References

1. Cooper PR, Nowak NJ, Higgins MJ, Church DM, Shows TB . Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes . Genomics . 49 . 3 . 419–29 . May 1998 . 9615227 . 10.1006/geno.1998.5291 .
2. Web site: Entrez Gene: SYT7 synaptotagmin VII.
3. Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K . SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms . The Journal of Biological Chemistry . 275 . 13 . 9823–31 . March 2000 . 10734137 . 10.1074/jbc.275.13.9823 . free .