SYT6 explained
Synaptotagmin-6 is a protein that in humans is encoded by the SYT6 gene.[1] [2]
Function
Synaptotagmins, such as SYT6, share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains. Some synaptotagmins are involved in synaptic membrane fusion, while others have a more general function in endocytosis. For further information on synaptotagmins, see MIM 185605.[supplied by OMIM]
Further reading
- Roggero CM, Tomes CN, De Blas GA, Castillo J, Michaut MA, Fukuda M, Mayorga LS . Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis . Developmental Biology . 285 . 2 . 422–35 . September 2005 . 16111671 . 10.1016/j.ydbio.2005.07.007 . free .
- Michaut M, De Blas G, Tomes CN, Yunes R, Fukuda M, Mayorga LS . Synaptotagmin VI participates in the acrosome reaction of human spermatozoa . Developmental Biology . 235 . 2 . 521–9 . July 2001 . 11437455 . 10.1006/dbio.2001.0316 . free .
- Perin MS . Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin . Biochemistry . 35 . 43 . 13808–16 . October 1996 . 8901523 . 10.1021/bi960853x .
- Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC . Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins . Nature . 375 . 6532 . 594–9 . June 1995 . 7791877 . 10.1038/375594a0 . 1995Natur.375..594L . 4265549 .
Notes and References
- Craxton M . Genomic analysis of synaptotagmin genes . Genomics . 77 . 1–2 . 43–9 . September 2001 . 11543631 . 10.1006/geno.2001.6619 .
- Web site: Entrez Gene: SYT6 synaptotagmin VI.
