SYT2 explained

Synaptotagmin-2 is a protein that in humans is encoded by the SYT2 gene.^{[1] [2]}

Further reading

• Fukuda M, Aruga J, Niinobe M, Aimoto S, Mikoshiba K . Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II . The Journal of Biological Chemistry . 269 . 46 . 29206–11 . November 1994 . 10.1016/S0021-9258(19)62031-4 . 7961887 . free .
• Perin MS . Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin . Biochemistry . 35 . 43 . 13808–16 . October 1996 . 8901523 . 10.1021/bi960853x .
• Baram D, Adachi R, Medalia O, Tuvim M, Dickey BF, Mekori YA, Sagi-Eisenberg R . Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells . The Journal of Experimental Medicine . 189 . 10 . 1649–58 . May 1999 . 10330444 . 2193646 . 10.1084/jem.189.10.1649 .
• Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K . SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms . The Journal of Biological Chemistry . 275 . 13 . 9823–31 . March 2000 . 10734137 . 10.1074/jbc.275.13.9823 . free .
• Kida Y, Sakaguchi M, Fukuda M, Mikoshiba K, Mihara K . Membrane topogenesis of a type I signal-anchor protein, mouse synaptotagmin II, on the endoplasmic reticulum . The Journal of Cell Biology . 150 . 4 . 719–30 . August 2000 . 10952998 . 2175286 . 10.1083/jcb.150.4.719 .
• Martina JA, Bonangelino CJ, Aguilar RC, Bonifacino JS . Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery . The Journal of Cell Biology . 153 . 5 . 1111–20 . May 2001 . 11381094 . 2174325 . 10.1083/jcb.153.5.1111 .
• Kida Y, Sakaguchi M, Fukuda M, Mikoshiba K, Mihara K . Amino acid residues before the hydrophobic region which are critical for membrane translocation of the N-terminal domain of synaptotagmin II . FEBS Letters . 507 . 3 . 341–5 . November 2001 . 11696368 . 10.1016/S0014-5793(01)03000-9 . 29026112 . free .
• Lindmark IM, Karlsson A, Serrander L, Francois P, Lew D, Rasmusson B, Stendahl O, Nüsse O . Synaptotagmin II could confer Ca(2+) sensitivity to phagocytosis in human neutrophils . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research . 1590 . 1–3 . 159–66 . June 2002 . 12063179 . 10.1016/S0167-4889(02)00209-4 .
• Rickman C, Archer DA, Meunier FA, Craxton M, Fukuda M, Burgoyne RD, Davletov B . Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate . The Journal of Biological Chemistry . 279 . 13 . 12574–9 . March 2004 . 14709554 . 10.1074/jbc.M310710200 . free .
• Lee BH, Min X, Heise CJ, Xu BE, Chen S, Shu H, Luby-Phelps K, Goldsmith EJ, Cobb MH . WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding . Molecular Cell . 15 . 5 . 741–51 . September 2004 . 15350218 . 10.1016/j.molcel.2004.07.018 . free .

Notes and References

1. Jones JM, Popma SJ, Mizuta M, Seino S, Meisler MH . Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19 . Mammalian Genome . 6 . 3 . 212–3 . March 1995 . 7749232 . 10.1007/BF00293017 . 2027.42/47020 . 24653745 . free .
2. Web site: Entrez Gene: SYT2 synaptotagmin II.