SYNGR1 explained

Synaptogyrin-1 is a protein that in humans is encoded by the SYNGR1 gene.^{[1] [2]}

This gene encodes an integral membrane protein associated with presynaptic vesicles in neuronal cells. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it functions in synaptic plasticity without being required for synaptic transmission. The gene product belongs to the synaptogyrin gene family. Three alternatively spliced variants encoding three different isoforms have been identified.^[3]

Further reading

• Dunham I, Shimizu N, Roe BA, etal . The DNA sequence of human chromosome 22. . Nature . 402 . 6761 . 489–95 . 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . free .
• Mirnics K, Middleton FA, Marquez A, etal . Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex. . Neuron . 28 . 1 . 53–67 . 2000 . 11086983 . 10.1016/S0896-6273(00)00085-4 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Verma R, Chauhan C, Saleem Q, etal . A nonsense mutation in the synaptogyrin 1 gene in a family with schizophrenia . Biol. Psychiatry . 55 . 2 . 196–9 . 2004 . 14732601 . 10.1016/j.biopsych.2003.10.012 . 26812099 .
• Collins JE, Wright CL, Edwards CA, etal . A genome annotation-driven approach to cloning the human ORFeome . Genome Biol. . 5 . 10 . R84 . 2005 . 15461802 . 10.1186/gb-2004-5-10-r84 . 545604 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Verma R, Kubendran S, Das SK, etal . SYNGR1 is associated with schizophrenia and bipolar disorder in southern India . J. Hum. Genet. . 50 . 12 . 635–40 . 2006 . 16215643 . 10.1007/s10038-005-0307-z . free .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Cheng MC, Chen CH . Identification of rare mutations of synaptogyrin 1 gene in patients with schizophrenia . Journal of Psychiatric Research . 41 . 12 . 1027–31 . 2007 . 17049558 . 10.1016/j.jpsychires.2006.08.010 .
• Chi A, Valencia JC, Hu ZZ, etal . Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes . J. Proteome Res. . 5 . 11 . 3135–44 . 2007 . 17081065 . 10.1021/pr060363j .

Notes and References

1. Kedra D, Pan HQ, Seroussi E, Fransson I, Guilbaud C, Collins JE, Dunham I, Blennow E, Roe BA, Piehl F, Dumanski JP . Characterization of the human synaptogyrin gene family . Hum Genet . 103 . 2 . 131–41 . Oct 1998 . 9760194 . 10.1007/s004390050795 . 2310048 .
2. Janz R, Sudhof TC, Hammer RE, Unni V, Siegelbaum SA, Bolshakov VY . Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I . Neuron . 24 . 3 . 687–700 . Jan 2000 . 10595519 . 10.1016/S0896-6273(00)81122-8 . free .
3. Web site: Entrez Gene: SYNGR1 synaptogyrin 1.