Vesicle-associated membrane protein 7 explained

Vesicle-associated membrane protein 7 (VAMP-7), is a protein that in humans is encoded by the VAMP7 gene also known as the SYBL1 gene.^{[1] [2] [3]}

Function

VAMP-7 is a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. VAMP-7 localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes.^[3]

Interactions

VAMP-7 has been shown to interact with SNAP23^{[4] [5]} and AP3D1.^[4]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Galli T, Zahraoui A, Vaidyanathan VV, Raposo G, Tian JM, Karin M, Niemann H, Louvard D . A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells . Mol. Biol. Cell . 9 . 6 . 1437–48 . 1998 . 9614185 . 25366 . 10.1091/mbc.9.6.1437 .
• Advani RJ, Yang B, Prekeris R, Lee KC, Klumperman J, Scheller RH . VAMP-7 mediates vesicular transport from endosomes to lysosomes . J. Cell Biol. . 146 . 4 . 765–76 . 1999 . 10459012 . 2156136 . 10.1083/jcb.146.4.765 .
• Matarazzo MR, Cuccurese M, Strazzullo M, Vacca M, Curci A, Miano MG, Cocchia M, Mercadante G, Torino A, D'Urso M, Ciccodicola A, D'Esposito M . Human and mouse SYBL1 gene structure and expression . Gene . 240 . 1 . 233–8 . 1999 . 10564831 . 10.1016/S0378-1119(99)00375-3 .
• Ciccodicola A, D'Esposito M, Esposito T, Gianfrancesco F, Migliaccio C, Miano MG, Matarazzo MR, Vacca M, Franzè A, Cuccurese M, Cocchia M, Curci A, Terracciano A, Torino A, Cocchia S, Mercadante G, Pannone E, Archidiacono N, Rocchi M, Schlessinger D, D'Urso M . Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region . Hum. Mol. Genet. . 9 . 3 . 395–401 . 2000 . 10655549 . 10.1093/hmg/9.3.395 . free .
• Ward DM, Pevsner J, Scullion MA, Vaughn M, Kaplan J . Syntaxin 7 and VAMP-7 are soluble N-ethylmaleimide-sensitive factor attachment protein receptors required for late endosome-lysosome and homotypic lysosome fusion in alveolar macrophages . Mol. Biol. Cell . 11 . 7 . 2327–33 . 2000 . 10888671 . 14922 . 10.1091/mbc.11.7.2327 .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Res. . 10 . 11 . 1788–95 . 2000 . 11076863 . 310948 . 10.1101/gr.143000 .
• Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R . A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function . EMBO J. . 19 . 23 . 6453–64 . 2000 . 11101518 . 305878 . 10.1093/emboj/19.23.6453 .
• Wade N, Bryant NJ, Connolly LM, Simpson RJ, Luzio JP, Piper RC, James DE . Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells . J. Biol. Chem. . 276 . 23 . 19820–7 . 2001 . 11278762 . 10.1074/jbc.M010838200 . free .
• Antonin W, Fasshauer D, Becker S, Jahn R, Schneider TR . Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs . Nat. Struct. Biol. . 9 . 2 . 107–11 . 2002 . 11786915 . 10.1038/nsb746 . 11858/00-001M-0000-0012-F459-F . 17724790 . free .
• Müller DJ, Schulze TG, Jahnes E, Cichon S, Krauss H, Kesper K, Held T, Maier W, Propping P, Nöthen MM, Rietschel M . Association between a polymorphism in the pseudoautosomal X-linked gene SYBL1 and bipolar affective disorder . Am. J. Med. Genet. . 114 . 1 . 74–8 . 2002 . 11840509 . 10.1002/ajmg.10115 .
• Bogdanovic A, Bennett N, Kieffer S, Louwagie M, Morio T, Garin J, Satre M, Bruckert F . Syntaxin 7, syntaxin 8, Vti1 and VAMP7 (vesicle-associated membrane protein 7) form an active SNARE complex for early macropinocytic compartment fusion in Dictyostelium discoideum . Biochem. J. . 368 . Pt 1 . 29–39 . 2002 . 12175335 . 1222979 . 10.1042/BJ20020845 .
• Matarazzo MR, De Bonis ML, Gregory RI, Vacca M, Hansen RS, Mercadante G, D'Urso M, Feil R, D'Esposito M . Allelic inactivation of the pseudoautosomal gene SYBL1 is controlled by epigenetic mechanisms common to the X and Y chromosomes . Hum. Mol. Genet. . 11 . 25 . 3191–8 . 2002 . 12444103 . 10.1093/hmg/11.25.3191 .
• Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V, Daviet L, Formstecher E, Hamburger A, Filippini F, D'Esposito M, Galli T . A dual mechanism controlling the localization and function of exocytic v-SNAREs . Proc. Natl. Acad. Sci. U.S.A. . 100 . 15 . 9011–6 . 2003 . 12853575 . 166429 . 10.1073/pnas.1431910100 . 2003PNAS..100.9011M . free .
• Di Leva F, Ferrante MI, Demarchi F, Caravelli A, Matarazzo MR, Giacca M, D'Urso M, D'Esposito M, Franzé A . Human synaptobrevin-like 1 gene basal transcription is regulated through the interaction of selenocysteine tRNA gene transcription activating factor-zinc finger 143 factors with evolutionary conserved cis-elements . J. Biol. Chem. . 279 . 9 . 7734–9 . 2004 . 14672948 . 10.1074/jbc.M308140200 . free .
• Rao SK, Huynh C, Proux-Gillardeaux V, Galli T, Andrews NW . Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis . J. Biol. Chem. . 279 . 19 . 20471–9 . 2004 . 14993220 . 10.1074/jbc.M400798200 . free .

Notes and References

1. D'Esposito M, Ciccodicola A, Gianfrancesco F, Esposito T, Flagiello L, Mazzarella R, Schlessinger D, D'Urso M . A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation . Nat. Genet. . 13 . 2 . 227–9 . Jul 1996 . 8640232 . 10.1038/ng0696-227 . 8466678 .
2. Filippini F, Rossi V, Galli T, Budillon A, D'Urso M, D'Esposito M . Longins: a new evolutionary conserved VAMP family sharing a novel SNARE domain . Trends Biochem. Sci. . 26 . 7 . 407–9 . Jul 2001 . 11440841 . 10.1016/S0968-0004(01)01861-8 .
3. Web site: Entrez Gene: SYBL1 synaptobrevin-like 1.
4. Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V, Daviet L, Formstecher E, Hamburger A, Filippini F, D'Esposito M, Galli T . A dual mechanism controlling the localization and function of exocytic v-SNAREs . Proc. Natl. Acad. Sci. U.S.A. . 100 . 15 . 9011–6 . Jul 2003 . 12853575 . 166429 . 10.1073/pnas.1431910100 . 2003PNAS..100.9011M . free .
5. Galli T, Zahraoui A, Vaidyanathan VV, Raposo G, Tian JM, Karin M, Niemann H, Louvard D . A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells . Mol. Biol. Cell . 9 . 6 . 1437–48 . Jun 1998 . 9614185 . 25366 . 10.1091/mbc.9.6.1437 .