SX-3228 explained

SX-3228 is a sedative and hypnotic drug used in scientific research. It has similar effects to sedative-hypnotic benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic.

SX-3228 is a subtype-selective GABAA positive allosteric modulator acting primarily at the α1 subtype. It thus has similar effects to other α1-selective drugs such as zolpidem and zaleplon in animal studies.[1] [2] It only partly substitutes for ethanol, and is a strong sedative-hypnotic with only limited anxiolytic effects which appear only at doses that also produce significant sedation.[3] [4]

References

  1. Sanger DJ . The effects of new hypnotic drugs in rats trained to discriminate ethanol . Behavioural Pharmacology . 8 . 4 . 287–92 . August 1997 . 9832988 . 10.1097/00008877-199708000-00002 . 42758930 .
  2. Griebel G, Perrault G, Tan S, Schoemaker H, Sanger DJ . Comparison of the pharmacological properties of classical and novel BZ-omega receptor ligands . Behavioural Pharmacology . 10 . 5 . 483–95 . September 1999 . 10780255 . 10.1097/00008877-199909000-00007 .
  3. Griebel G, Perrault G, Sanger DJ . Limited anxiolytic-like effects of non-benzodiazepine hypnotics in rodents . Journal of Psychopharmacology . 12 . 4 . 356–65 . 1998 . 10065909 . 10.1177/026988119801200405 . 269304 .
  4. Alvariño F, Monti JM, Jantos H, Monti D . Effect of SX-3228, a selective ligand for the BZ1 receptor, on sleep and waking during the light-dark cycle in the rat . Brazilian Journal of Medical and Biological Research . 32 . 8 . 1007–14 . August 1999 . 10454763 . 10.1590/s0100-879x1999000800011 . free .

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