SURF6 explained

Surfeit locus protein 6 is a protein that in humans is encoded by the SURF6 gene.^[1]

This gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. The gene demonstrates features of a housekeeping gene, being ubiquitously expressed, and the encoded protein has been localized to the nucleolus. The protein includes motifs found in both the mouse and fish orthologs, which suggests a putative function as a nucleolar-matrix protein with nucleic acid-binding properties, based on characteristics determined in mouse.^[2]

Further reading

• Yon J, Jones T, Garson K, etal . The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1. . Hum. Mol. Genet. . 2 . 3 . 237–40 . 1993 . 8499913 . 10.1093/hmg/2.3.237 .
• Magoulas C, Fried M . The Surf-6 gene of the mouse surfeit locus encodes a novel nucleolar protein. . DNA Cell Biol. . 15 . 4 . 305–16 . 1996 . 8639267 . 10.1089/dna.1996.15.305 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Magoulas C, Zatsepina OV, Jordan PW, etal . The SURF-6 protein is a component of the nucleolar matrix and has a high binding capacity for nucleic acids in vitro. . Eur. J. Cell Biol. . 75 . 2 . 174–83 . 1998 . 9548374 . 10.1016/s0171-9335(98)80059-9.
• Magoulas C, Fried M . Isolation and genomic analysis of the human surf-6 gene: a member of the Surfeit locus. . Gene . 243 . 1–2 . 115–23 . 2000 . 10675619 . 10.1016/S0378-1119(99)00551-X .
• Andersen JS, Lyon CE, Fox AH, etal . Directed proteomic analysis of the human nucleolus . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . 14132033 . free . 2002CBio...12....1A .
• Angiolillo A, Russo G, Porcellini A, etal . The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts . Gene . 284 . 1–2 . 169–78 . 2002 . 11891058 . 10.1016/S0378-1119(02)00379-7 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Andersen JS, Lam YW, Leung AK, etal . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .

Notes and References

1. Duhig T, Ruhrberg C, Mor O, Fried M . The human Surfeit locus . Genomics . 52 . 1 . 72–8 . May 1999 . 9740673 . 10.1006/geno.1998.5372 .
2. Web site: Entrez Gene: SURF6 surfeit 6.