SUPT4H1 explained

Transcription elongation factor SPT4 is a protein that in humans is encoded by the SUPT4H1 gene.^{[1] [2]}

Further reading

• Hartzog GA, Basrai MA, Ricupero-Hovasse SL, etal . Identification and analysis of a functional human homolog of the SPT4 gene of Saccharomyces cerevisiae . Mol. Cell. Biol. . 16 . 6 . 2848–56 . 1996 . 8649394 . 10.1128/MCB.16.6.2848. 231277 .
• Wada T, Takagi T, Yamaguchi Y, etal . DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs . Genes Dev. . 12 . 3 . 343–56 . 1998 . 9450929 . 10.1101/gad.12.3.343 . 316480 .
• Wada T, Takagi T, Yamaguchi Y, etal . Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro . EMBO J. . 17 . 24 . 7395–403 . 1999 . 9857195 . 10.1093/emboj/17.24.7395 . 1171084 .
• Yamaguchi Y, Wada T, Watanabe D, etal . Structure and function of the human transcription elongation factor DSIF . J. Biol. Chem. . 274 . 12 . 8085–92 . 1999 . 10075709 . 10.1074/jbc.274.12.8085 . free .
• Yamaguchi Y, Takagi T, Wada T, etal . NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation . Cell . 97 . 1 . 41–51 . 1999 . 10199401 . 10.1016/S0092-8674(00)80713-8 . 16855257 . free .
• Kim JB, Yamaguchi Y, Wada T, etal . Tat-SF1 Protein Associates with RAP30 and Human SPT5 Proteins . Mol. Cell. Biol. . 19 . 9 . 5960–8 . 1999 . 10454543 . 10.1128/mcb.19.9.5960. 84462 .
• Richard Gaynor . Ivanov D, Kwak YT, Guo J, Gaynor RB . Domains in the SPT5 Protein That Modulate Its Transcriptional Regulatory Properties . Mol. Cell. Biol. . 20 . 9 . 2970–83 . 2000 . 10757782 . 10.1128/MCB.20.9.2970-2983.2000 . 85557 .
• Wada T, Orphanides G, Hasegawa J, etal . FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH . Mol. Cell . 5 . 6 . 1067–72 . 2000 . 10912001 . 10.1016/S1097-2765(00)80272-5 . free .
• Ping YH, Rana TM . DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation . J. Biol. Chem. . 276 . 16 . 12951–8 . 2001 . 11112772 . 10.1074/jbc.M006130200 . free .
• Renner DB, Yamaguchi Y, Wada T, etal . A highly purified RNA polymerase II elongation control system . J. Biol. Chem. . 276 . 45 . 42601–9 . 2001 . 11553615 . 10.1074/jbc.M104967200 . free .
• Mo X, Dynan WS . Subnuclear Localization of Ku Protein: Functional Association with RNA Polymerase II Elongation Sites . Mol. Cell. Biol. . 22 . 22 . 8088–99 . 2002 . 12391174 . 10.1128/MCB.22.22.8088-8099.2002 . 134733 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Narita T, Yamaguchi Y, Yano K, etal . Human Transcription Elongation Factor NELF: Identification of Novel Subunits and Reconstitution of the Functionally Active Complex . Mol. Cell. Biol. . 23 . 6 . 1863–73 . 2003 . 12612062 . 10.1128/MCB.23.6.1863-1873.2003 . 149481 .
• Kim DK, Inukai N, Yamada T, etal . Structure-function analysis of human Spt4: evidence that hSpt4 and hSpt5 exert their roles in transcriptional elongation as parts of the DSIF complex . Genes Cells . 8 . 4 . 371–8 . 2004 . 12653964 . 10.1046/j.1365-2443.2003.00638.x . 42100130 . free .
• Kwak YT, Guo J, Prajapati S, etal . Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties . Mol. Cell . 11 . 4 . 1055–66 . 2003 . 12718890 . 10.1016/S1097-2765(03)00101-1 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Endoh M, Zhu W, Hasegawa J, etal . Human Spt6 Stimulates Transcription Elongation by RNA Polymerase II In Vitro . Mol. Cell. Biol. . 24 . 8 . 3324–36 . 2004 . 15060154 . 10.1128/MCB.24.8.3324-3336.2004 . 381665 .
• Mandal SS, Chu C, Wada T, etal . Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II . Proc. Natl. Acad. Sci. U.S.A. . 101 . 20 . 7572–7 . 2004 . 15136722 . 10.1073/pnas.0401493101 . 419647 . free . 2004PNAS..101.7572M .
• Jennings BH, Shah S, Yamaguchi Y, etal . Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila . Curr. Biol. . 14 . 18 . 1680–4 . 2005 . 15380072 . 10.1016/j.cub.2004.08.066 . 18780732 . free .

Notes and References

1. Chiang PW, Wang SQ, Smithivas P, Song WJ, Crombez E, Akhtar A, Im R, Greenfield J, Ramamoorthy S, Van Keuren M, Blackburn CC, Tsai CH, Kurnit DM . Isolation and characterization of the human and mouse homologues (SUPT4H and Supt4h) of the yeast SPT4 gene . Genomics . 34 . 3 . 368–75 . Sep 1996 . 8786137 . 10.1006/geno.1996.0299 .
2. Web site: Entrez Gene: SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae).