Transcription initiation protein SPT3 homolog explained

Transcription initiation protein SPT3 homolog is a protein that in humans is encoded by the SUPT3H gene.^{[1] [2] [3]}

Interactions

Transcription initiation protein SPT3 homolog has been shown to interact with GCN5L2,^{[4] [5]} TAF6L,^[5] TADA3L,^[5] TAF5L,^[5] SF3B3,^[5] SUPT7L,^[5] Myc,^[6] TAF9,^[5] Transformation/transcription domain-associated protein,^[5] TAF12,^[5] TAF10,^{[4] [5]} TAF4^[4] and DDB1.^[5]

Further reading

• Yu J, Madison JM, Mundlos S, Winston F, Olsen BR . Characterization of a human homologue of the Saccharomyces cerevisiae transcription factor spt3 (SUPT3H) . Genomics . 53 . 1 . 90–6 . Oct 1998 . 9787080 . 10.1006/geno.1998.5500 .
• Vassilev A, Yamauchi J, Kotani T, Prives C, Avantaggiati ML, Qin J, Nakatani Y . The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily . Molecular Cell . 2 . 6 . 869–75 . Dec 1998 . 9885574 . 10.1016/S1097-2765(00)80301-9 . free .
• Brand M, Yamamoto K, Staub A, Tora L . Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction . The Journal of Biological Chemistry . 274 . 26 . 18285–9 . Jun 1999 . 10373431 . 10.1074/jbc.274.26.18285 . free .
• Speek M . Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes . Molecular and Cellular Biology . 21 . 6 . 1973–85 . Mar 2001 . 11238933 . 86790 . 10.1128/MCB.21.6.1973-1985.2001 .
• Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L . UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation . The EMBO Journal . 20 . 12 . 3187–96 . Jun 2001 . 11406595 . 150203 . 10.1093/emboj/20.12.3187 .
• Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG . Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo . Molecular and Cellular Biology . 21 . 20 . 6782–95 . Oct 2001 . 11564863 . 99856 . 10.1128/MCB.21.20.6782-6795.2001 .
• Cavusoglu N, Brand M, Tora L, Van Dorsselaer A . Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis . Proteomics . 3 . 2 . 217–23 . Feb 2003 . 12601814 . 10.1002/pmic.200390030 . 6035986 .
• Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E . c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation . The Journal of Biological Chemistry . 278 . 22 . 20405–12 . May 2003 . 12660246 . 4031917 . 10.1074/jbc.M211795200 . free .

Notes and References

1. Ogryzko VV, Kotani T, Zhang X, Schiltz RL, Howard T, Yang XJ, Howard BH, Qin J, Nakatani Y . Histone-like TAFs within the PCAF histone acetylase complex . Cell . 94 . 1 . 35–44 . Jul 1998 . 9674425 . 10.1016/S0092-8674(00)81219-2 . 18942972 . free .
2. Martinez E, Kundu TK, Fu J, Roeder RG . A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID . The Journal of Biological Chemistry . 273 . 37 . 23781–5 . Sep 1998 . 9726987 . 10.1074/jbc.273.37.23781 . free .
3. Web site: Entrez Gene: SUPT3H suppressor of Ty 3 homolog (S. cerevisiae).
4. Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L . UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation . The EMBO Journal . 20 . 12 . 3187–96 . Jun 2001 . 11406595 . 150203 . 10.1093/emboj/20.12.3187 .
5. Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG . Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo . Molecular and Cellular Biology . 21 . 20 . 6782–95 . Oct 2001 . 11564863 . 99856 . 10.1128/MCB.21.20.6782-6795.2001 .
6. Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E . c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation . The Journal of Biological Chemistry . 278 . 22 . 20405–12 . May 2003 . 12660246 . 4031917 . 10.1074/jbc.M211795200 . free .