SULT4A1 explained

Sulfotransferase 4A1 is an enzyme that in humans is encoded by the SULT4A1 gene.^{[1] [2]}

This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia.

Further reading

• Weinshilboum RM, Otterness DM, Aksoy IA, etal . Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. . FASEB J. . 11 . 1 . 3–14 . 1997 . 9034160 . 10.1096/fasebj.11.1.9034160. free . 3977677 .
• Glatt H, Engelke CE, Pabel U, etal . Sulfotransferases: genetics and role in toxicology. . Toxicol. Lett. . 112–113 . 1–3. 341–8 . 2000 . 10720750 . 10.1016/S0378-4274(99)00214-3 .
• Glatt H . Sulfotransferases in the bioactivation of xenobiotics. . Chem. Biol. Interact. . 129 . 1–2 . 141–70 . 2001 . 11154739 . 10.1016/S0009-2797(00)00202-7 . 2000CBI...129..141G .
• Glatt H, Boeing H, Engelke CE, etal . Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects. . Mutat. Res. . 482 . 1–2 . 27–40 . 2001 . 11535246 . 10.1016/S0027-5107(01)00207-X .
• Dunham I, Shimizu N, Roe BA, etal . The DNA sequence of human chromosome 22. . Nature . 402 . 6761 . 489–95 . 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . free .
• Sakakibara Y, Suiko M, Pai TG, etal . Highly conserved mouse and human brain sulfotransferases: molecular cloning, expression, and functional characterization. . Gene . 285 . 1–2 . 39–47 . 2002 . 12039030 . 10.1016/S0378-1119(02)00431-6 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Collins JE, Goward ME, Cole CG, etal . Reevaluating human gene annotation: a second-generation analysis of chromosome 22. . Genome Res. . 13 . 1 . 27–36 . 2003 . 12529303 . 10.1101/gr.695703 . 430954 .
• Liyou NE, Buller KM, Tresillian MJ, etal . Localization of a brain sulfotransferase, SULT4A1, in the human and rat brain: an immunohistochemical study. . J. Histochem. Cytochem. . 51 . 12 . 1655–64 . 2004 . 14623933 . 10.1177/002215540305101209. free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Collins JE, Wright CL, Edwards CA, etal . A genome annotation-driven approach to cloning the human ORFeome. . Genome Biol. . 5 . 10 . R84 . 2005 . 15461802 . 10.1186/gb-2004-5-10-r84 . 545604 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Brennan MD, Condra J . Transmission disequilibrium suggests a role for the sulfotransferase-4A1 gene in schizophrenia. . Am. J. Med. Genet. B Neuropsychiatr. Genet. . 139 . 1 . 69–72 . 2006 . 16152568 . 10.1002/ajmg.b.30222 . 8927459 .
• Allali-Hassani A, Pan PW, Dombrovski L, etal . Structural and chemical profiling of the human cytosolic sulfotransferases. . PLOS Biol. . 5 . 5 . e97 . 2007 . 17425406 . 10.1371/journal.pbio.0050097 . 1847840 . free .

Notes and References

1. Falany CN, Xie X, Wang J, Ferrer J, Falany JL . Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain . 346 . Biochem J . Pt 3 . 857–64 . May 2000 . 3 . 10.1042/bj3460857 . 10698717 . 1220923 .
2. Web site: Entrez Gene: SULT4A1 sulfotransferase family 4A, member 1.