SULT2B1 explained

Sulfotransferase family cytosolic 2B member 1 is an enzyme that in humans is encoded by the SULT2B1 gene.^[1]

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic chemical compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described.^[2]

See also

• Steroid sulfotransferase
• Steroidogenic enzyme

Further reading

• Weinshilboum RM, Otterness DM, Aksoy IA, etal . Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. . FASEB J. . 11 . 1 . 3–14 . 1997 . 9034160 . 10.1096/fasebj.11.1.9034160. free . 12532583 .
• Glatt H, Engelke CE, Pabel U, etal . Sulfotransferases: genetics and role in toxicology. . Toxicol. Lett. . 112-113 . 341–8 . 2000 . 10720750 . 10.1016/S0378-4274(99)00214-3 .
• Glatt H . Sulfotransferases in the bioactivation of xenobiotics. . Chem. Biol. Interact. . 129 . 1–2 . 141–70 . 2001 . 11154739 . 10.1016/S0009-2797(00)00202-7 . 2000CBI...129..141G .
• Glatt H, Boeing H, Engelke CE, etal . Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects . Mutat. Res. . 482 . 1–2 . 27–40 . 2001 . 11535246 . 10.1016/S0027-5107(01)00207-X.
• Meloche CA, Falany CN . Expression and characterization of the human 3 beta-hydroxysteroid sulfotransferases (SULT2B1a and SULT2B1b) . J. Steroid Biochem. Mol. Biol. . 77 . 4–5 . 261–9 . 2001 . 11457664 . 10.1016/S0960-0760(01)00064-4 . 20589491 .
• Geese WJ, Raftogianis RB . Biochemical characterization and tissue distribution of human SULT2B1 . Biochem. Biophys. Res. Commun. . 288 . 1 . 280–9 . 2001 . 11594786 . 10.1006/bbrc.2001.5746 .
• Fuda H, Lee YC, Shimizu C, etal . Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase . J. Biol. Chem. . 277 . 39 . 36161–6 . 2002 . 12145317 . 10.1074/jbc.M207165200 . free .
• Pai TG, Sugahara T, Suiko M, etal . Differential xenoestrogen-sulfating activities of the human cytosolic sulfotransferases: molecular cloning, expression, and purification of human SULT2B1a and SULT2B1b sulfotransferases . Biochim. Biophys. Acta . 1573 . 2 . 165–70 . 2003 . 12399026 . 10.1016/s0304-4165(02)00416-6.
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Lee KA, Fuda H, Lee YC, etal . Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms . J. Biol. Chem. . 278 . 45 . 44593–9 . 2004 . 12923182 . 10.1074/jbc.M308312200 . free .
• Yanai H, Javitt NB, Higashi Y, etal . Expression of cholesterol sulfotransferase (SULT2B1b) in human platelets . Circulation . 109 . 1 . 92–6 . 2004 . 14676143 . 10.1161/01.CIR.0000108925.95658.8D . 14696645 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• He D, Meloche CA, Dumas NA, etal . Different subcellular localization of sulphotransferase 2B1b in human placenta and prostate . Biochem. J. . 379 . Pt 3 . 533–40 . 2004 . 14741047 . 10.1042/BJ20031524 . 1224114 .
• Grimwood J, Gordon LA, Olsen A, etal . The DNA sequence and biology of human chromosome 19 . Nature . 428 . 6982 . 529–35 . 2004 . 15057824 . 10.1038/nature02399 . 2004Natur.428..529G . free .
• Higashi Y, Fuda H, Yanai H, etal . Expression of cholesterol sulfotransferase (SULT2B1b) in human skin and primary cultures of human epidermal keratinocytes . J. Invest. Dermatol. . 122 . 5 . 1207–13 . 2004 . 15140224 . 10.1111/j.0022-202X.2004.22416.x . free .

Notes and References

1. Her C, Wood TC, Eichler EE, Mohrenweiser HW, Ramagli LS, Siciliano MJ, Weinshilboum RM . Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene . Genomics . 53 . 3 . 284–95 . Dec 1998 . 9799594 . 10.1006/geno.1998.5518 .
2. Web site: Entrez Gene: SULT2B1 sulfotransferase family, cytosolic, 2B, member 1.