SULT1C4 explained

Sulfotransferase 1C4 is an enzyme that in humans is encoded by the SULT1C4 gene.^{[1] [2] [3]}

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities.

The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds.

Further reading

• Weinshilboum RM, Otterness DM, Aksoy IA, etal . Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. . FASEB J. . 11 . 1 . 3–14 . 1997 . 9034160 . 10.1096/fasebj.11.1.9034160. free . 12532583 .
• Glatt H, Engelke CE, Pabel U, etal . Sulfotransferases: genetics and role in toxicology. . Toxicol. Lett. . 112–113 . 341–8 . 2000 . 10720750 . 10.1016/S0378-4274(99)00214-3 .
• Glatt H . Sulfotransferases in the bioactivation of xenobiotics. . Chem. Biol. Interact. . 129 . 1–2 . 141–70 . 2001 . 11154739 . 10.1016/S0009-2797(00)00202-7 .
• Glatt H, Boeing H, Engelke CE, etal . Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects . Mutat. Res. . 482 . 1–2 . 27–40 . 2001 . 11535246 . 10.1016/S0027-5107(01)00207-X.
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Hillier LW, Graves TA, Fulton RS, etal . Generation and annotation of the DNA sequences of human chromosomes 2 and 4 . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . 2005Natur.434..724H . free .
• Allali-Hassani A, Pan PW, Dombrovski L, etal . Structural and chemical profiling of the human cytosolic sulfotransferases . PLOS Biol. . 5 . 5 . e97 . 2007 . 17425406 . 10.1371/journal.pbio.0050097 . 1847840 . free .

Notes and References

1. Freimuth RR, Raftogianis RB, Wood TC, Moon E, Kim UJ, Xu J, Siciliano MJ, Weinshilboum RM . Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization . Genomics . 65 . 2 . 157–65 . Jul 2000 . 10783263 . 10.1006/geno.2000.6150 .
2. Sakakibara Y, Yanagisawa K, Katafuchi J, Ringer DP, Takami Y, Nakayama T, Suiko M, Liu MC . Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene . J Biol Chem . 273 . 51 . 33929–35 . Jan 1999 . 9852044 . 10.1074/jbc.273.51.33929 . free .
3. Web site: Entrez Gene: SULT1C2 sulfotransferase family, cytosolic, 1C, member 2.