SULT1C2 explained

Sulfotransferase 1C2 is an enzyme that in humans is encoded by the SULT1C2 gene.^{[1] [2] [3]}

Function

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[3]

Further reading

• Weinshilboum RM, Otterness DM, Aksoy IA, Wood TC, Her C, Raftogianis RB . Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes . FASEB Journal . 11 . 1 . 3–14 . January 1997 . 9034160 . 10.1096/fasebj.11.1.9034160. free . 12532583 .
• Glatt H, Engelke CE, Pabel U, Teubner W, Jones AL, Coughtrie MW, Andrae U, Falany CN, Meinl W . Sulfotransferases: genetics and role in toxicology . Toxicology Letters . 112-113 . 341–8 . March 2000 . 10720750 . 10.1016/S0378-4274(99)00214-3 .
• Glatt H . Sulfotransferases in the bioactivation of xenobiotics . Chemico-Biological Interactions . 129 . 1–2 . 141–70 . December 2000 . 11154739 . 10.1016/S0009-2797(00)00202-7 . 2000CBI...129..141G .
• Glatt H, Boeing H, Engelke CE, Ma L, Kuhlow A, Pabel U, Pomplun D, Teubner W, Meinl W . Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects . Mutation Research . 482 . 1–2 . 27–40 . October 2001 . 11535246 . 10.1016/S0027-5107(01)00207-X .
• Kiehlbauch CC, Lam YF, Ringer DP . Homodimeric and heterodimeric aryl sulfotransferases catalyze the sulfuric acid esterification of N-hydroxy-2-acetylaminofluorene . The Journal of Biological Chemistry . 270 . 32 . 18941–7 . August 1995 . 7642552 . 10.1074/jbc.270.32.18941 . free .
• Yoshinari K, Nagata K, Shimada M, Yamazoe Y . Molecular characterization of ST1C1-related human sulfotransferase . Carcinogenesis . 19 . 5 . 951–3 . May 1998 . 9635888 . 10.1093/carcin/19.5.951 . free .
• Sakakibara Y, Yanagisawa K, Katafuchi J, Ringer DP, Takami Y, Nakayama T, Suiko M, Liu MC . Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene . The Journal of Biological Chemistry . 273 . 51 . 33929–35 . December 1998 . 9852044 . 10.1074/jbc.273.51.33929 . free .
• Hehonah N, Zhu X, Brix L, Bolton-Grob R, Barnett A, Windmill K, McManus M . Molecular cloning, expression, localisation and functional characterisation of a rabbit SULT1C2 sulfotransferase . The International Journal of Biochemistry & Cell Biology . 31 . 8 . 869–82 . August 1999 . 10481272 . 10.1016/S1357-2725(99)00038-2 .
• Li X, Clemens DL, Anderson RJ . Sulfation of iodothyronines by human sulfotransferase 1C1 (SULT1C1)* . Biochemical Pharmacology . 60 . 11 . 1713–6 . December 2000 . 11077054 . 10.1016/S0006-2952(00)00475-5 .
• Freimuth RR, Eckloff B, Wieben ED, Weinshilboum RM . Human sulfotransferase SULT1C1 pharmacogenetics: gene resequencing and functional genomic studies . Pharmacogenetics . 11 . 9 . 747–56 . December 2001 . 11740338 . 10.1097/00008571-200112000-00002 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Dombrovski L, Dong A, Bochkarev A, Plotnikov AN . Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP) . Proteins . 64 . 4 . 1091–4 . September 2006 . 16804942 . 10.1002/prot.21048 . 32647194 . free .

Notes and References

1. Her C, Kaur GP, Athwal RS, Weinshilboum RM . Human sulfotransferase SULT1C1: cDNA cloning, tissue-specific expression, and chromosomal localization . Genomics . 41 . 3 . 467–70 . May 1997 . 9169148 . 10.1006/geno.1997.4683 .
2. Freimuth RR, Raftogianis RB, Wood TC, Moon E, Kim UJ, Xu J, Siciliano MJ, Weinshilboum RM . Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization . Genomics . 65 . 2 . 157–65 . April 2000 . 10783263 . 10.1006/geno.2000.6150 .
3. Web site: Entrez Gene: SULT1C1 sulfotransferase family, cytosolic, 1C, member 1.