SULT1B1 explained

Sulfotransferase family cytosolic 1B member 1 is an enzyme that in humans is encoded by the SULT1B1 gene.^{[1] [2] [3]}

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of all of the other SULT1 genes.

Further reading

• Weinshilboum RM, Otterness DM, Aksoy IA, etal . Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. . FASEB J. . 11 . 1 . 3–14 . 1997 . 9034160 . 10.1096/fasebj.11.1.9034160. free . 12532583 .
• Glatt H, Engelke CE, Pabel U, etal . Sulfotransferases: genetics and role in toxicology. . Toxicol. Lett. . 112-113 . 1–3. 341–8 . 2000 . 10720750 . 10.1016/S0378-4274(99)00214-3 .
• Glatt H . Sulfotransferases in the bioactivation of xenobiotics. . Chem. Biol. Interact. . 129 . 1–2 . 141–70 . 2001 . 11154739 . 10.1016/S0009-2797(00)00202-7 . 2000CBI...129..141G .
• Glatt H, Boeing H, Engelke CE, etal . Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects. . Mutat. Res. . 482 . 1–2 . 27–40 . 2001 . 11535246 . 10.1016/S0027-5107(01)00207-X .
• Wang J, Falany JL, Falany CN . Expression and characterization of a novel thyroid hormone-sulfating form of cytosolic sulfotransferase from human liver. . Mol. Pharmacol. . 53 . 2 . 274–82 . 1998 . 9463486 . 10.1124/mol.53.2.274.
• Tsoi C, Falany CN, Morgenstern R, Swedmark S . Molecular cloning, expression, and characterization of a canine sulfotransferase that is a human ST1B2 ortholog. . Arch. Biochem. Biophys. . 390 . 1 . 87–92 . 2001 . 11368519 . 10.1006/abbi.2001.2373 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Dombrovski L, Dong A, Bochkarev A, Plotnikov AN . Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP). . Proteins . 64 . 4 . 1091–4 . 2006 . 16804942 . 10.1002/prot.21048 . 32647194 . free .
• Allali-Hassani A, Pan PW, Dombrovski L, etal . Structural and chemical profiling of the human cytosolic sulfotransferases. . PLOS Biol. . 5 . 5 . e97 . 2007 . 17425406 . 10.1371/journal.pbio.0050097 . 1847840 . free .

Notes and References

1. Meinl W, Glatt H . Structure and localization of the human SULT1B1 gene: neighborhood to SULT1E1 and a SULT1D pseudogene . Biochem Biophys Res Commun . 288 . 4 . 855–62 . Nov 2001 . 11688987 . 10.1006/bbrc.2001.5829 .
2. Fujita K, Nagata K, Ozawa S, Sasano H, Yamazoe Y . Molecular cloning and characterization of rat ST1B1 and human ST1B2 cDNAs, encoding thyroid hormone sulfotransferases . J Biochem . 122 . 5 . 1052–61 . Feb 1998 . 9443824 . 10.1093/oxfordjournals.jbchem.a021846.
3. Web site: Entrez Gene: SULT1B1 sulfotransferase family, cytosolic, 1B, member 1.