SULF2 explained

Extracellular sulfatase Sulf-2 is an enzyme that in humans is encoded by the SULF2 gene.^{[1] [2]}

Function

Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005).[supplied by OMIM]

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones . DNA Research . 9 . 3 . 99–106 . June 2002 . 12168954 . 10.1093/dnares/9.3.99 . 10.1.1.500.923 .
• Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Research . 6 . 5 . 337–345 . October 1999 . 10574462 . 10.1093/dnares/6.5.337 . free .
• Fossey SC, Mychaleckyj JC, Pendleton JK, Snyder JR, Bensen JT, Hirakawa S, Rich SS, Freedman BI, Bowden DW . A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20 . Genomics . 76 . 1–3 . 45–57 . August 2001 . 11549316 . 10.1006/geno.2001.6584 .
• Dai Y, Yang Y, MacLeod V, Yue X, Rapraeger AC, Shriver Z, Venkataraman G, Sasisekharan R, Sanderson RD . HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo . The Journal of Biological Chemistry . 280 . 48 . 40066–40073 . December 2005 . 16192265 . 10.1074/jbc.M508136200 . free .
• Morimoto-Tomita M, Uchimura K, Bistrup A, Lum DH, Egeblad M, Boudreau N, Werb Z, Rosen SD . Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer . Neoplasia . 7 . 11 . 1001–1010 . November 2005 . 16331886 . 1502017 . 10.1593/neo.05496 .
• Uchimura K, Morimoto-Tomita M, Bistrup A, Li J, Lyon M, Gallagher J, Werb Z, Rosen SD . HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1 . BMC Biochemistry . 7 . 2 . 2006 . 16417632 . 1386684 . 10.1186/1471-2091-7-2 . free .

Notes and References

1. Morimoto-Tomita M, Uchimura K, Werb Z, Hemmerich S, Rosen SD . Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans . The Journal of Biological Chemistry . 277 . 51 . 49175–49185 . December 2002 . 12368295 . 2779716 . 10.1074/jbc.M205131200 . free .
2. Web site: Entrez Gene: SULF2 sulfatase 2.