SUGT1 explained

Suppressor of G2 allele of SKP1 homolog is a protein that in humans is encoded by the SUGT1 gene.^{[1] [2]}

Function

This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions.^[3]

Interactions

SUGT1 has been shown to interact with S100A6.^[4]

Further reading

• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nature Biotechnology . 21 . 5 . 566–9 . May 2003 . 12665801 . 10.1038/nbt810 . 23783563 .
• Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J . Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins . The Journal of Biological Chemistry . 278 . 29 . 26923–8 . July 2003 . 12746458 . 10.1074/jbc.M211518200 . free .
• Niikura Y, Kitagawa K . Identification of a novel splice variant: human SGT1B (SUGT1B) . DNA Sequence . 14 . 6 . 436–41 . December 2003 . 15018354 . 10.1080/10425170310001623644 . 20578581 .
• Zou X, Ji C, Wang L, Wu M, Zheng H, Xu J, Jin F, Gu S, Ying K, Xie Y, Mao Y . Molecular cloning and characterization of SGT1.2, a novel splice variant of Homo sapiens SGT1 . DNA Sequence . 15 . 2 . 140–3 . April 2004 . 15346769 . 10.1080/1042517032000160215 . 37324928 .
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells . Nature Biotechnology . 23 . 1 . 94–101 . January 2005 . 15592455 . 10.1038/nbt1046 . 7200157 .
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nature Biotechnology . 24 . 10 . 1285–92 . October 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• da Silva Correia J, Miranda Y, Leonard N, Ulevitch R . SGT1 is essential for Nod1 activation . Proceedings of the National Academy of Sciences of the United States of America . 104 . 16 . 6764–9 . April 2007 . 17420470 . 1871859 . 10.1073/pnas.0610926104 . 2007PNAS..104.6764D . free .
• Spiechowicz M, Zylicz A, Bieganowski P, Kuznicki J, Filipek A . Hsp70 is a new target of Sgt1--an interaction modulated by S100A6 . Biochemical and Biophysical Research Communications . 357 . 4 . 1148–53 . June 2007 . 17466273 . 10.1016/j.bbrc.2007.04.073 .

Notes and References

1. Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P . SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex . Molecular Cell . 4 . 1 . 21–33 . July 1999 . 10445024 . 10.1016/S1097-2765(00)80184-7 . free .
2. Web site: Entrez Gene: SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae).
3. Web site: Entrez Gene: SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae).
4. Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J . Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins . The Journal of Biological Chemistry . 278 . 29 . 26923–8 . July 2003 . 12746458 . 10.1074/jbc.M211518200 . free .