SUDS3 explained

Sin3 histone deacetylase corepressor complex component SDS3 is an enzyme that in humans is encoded by the SUDS3 gene.^{[1] [2]}

Function

SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003).[supplied by OMIM]^[2]

Interactions

SUDS3 has been shown to interact with HDAC1,^[3] Host cell factor C1,^[4] SIN3B^[1] and SIN3A.^{[1] [3]}

Further reading

• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . November 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Fleischer TC, Yun UJ, Ayer DE . Identification and characterization of three new components of the mSin3A corepressor complex . Molecular and Cellular Biology . 23 . 10 . 3456–67 . May 2003 . 12724404 . 164750 . 10.1128/MCB.23.10.3456-3467.2003 .
• Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W . Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 . Genes & Development . 17 . 7 . 896–911 . April 2003 . 12670868 . 196026 . 10.1101/gad.252103 .
• Hattori A, Okumura K, Nagase T, Kikuno R, Hirosawa M, Ohara O . Characterization of long cDNA clones from human adult spleen . DNA Research . 7 . 6 . 357–66 . December 2000 . 11214971 . 10.1093/dnares/7.6.357 . free .

Notes and References

1. Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA . Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex . Molecular and Cellular Biology . 22 . 8 . 2743–50 . April 2002 . 11909966 . 133736 . 10.1128/MCB.22.8.2743-2750.2002 .
2. Web site: Entrez Gene: SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae).
3. Fleischer TC, Yun UJ, Ayer DE . Identification and characterization of three new components of the mSin3A corepressor complex . Molecular and Cellular Biology . 23 . 10 . 3456–67 . May 2003 . 12724404 . 164750 . 10.1128/MCB.23.10.3456-3467.2003 .
4. Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W . Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 . Genes & Development . 17 . 7 . 896–911 . April 2003 . 12670868 . 196026 . 10.1101/gad.252103 .