STX11 explained

Syntaxin 11, also known as STX11, is a human gene that is a member of the t-SNARE family.^[1]

Interactions

STX11 has been shown to interact with SNAP25^{[2] [3]} and SNAP23.^{[2] [4]}

See also

• Hemophagocytic lymphohistiocytosis
• Peutz–Jeghers syndrome

Further reading

• Advani RJ, Bae HR, Bock JB, Chao DS, Doung YC, Prekeris R, Yoo JS, Scheller RH . Seven novel mammalian SNARE proteins localize to distinct membrane compartments . The Journal of Biological Chemistry . 273 . 17 . 10317–24 . Apr 1998 . 9553086 . 10.1074/jbc.273.17.10317 . free .
• Tang BL, Low DY, Hong W . Syntaxin 11: a member of the syntaxin family without a carboxyl terminal transmembrane domain . Biochemical and Biophysical Research Communications . 245 . 2 . 627–32 . Apr 1998 . 9571206 . 10.1006/bbrc.1998.8490 .
• Valdez AC, Cabaniols JP, Brown MJ, Roche PA . Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network . Journal of Cell Science . 112 . 6 . 845–54 . Mar 1999 . 10.1242/jcs.112.6.845 . 10036234 .
• Martín-Martín B, Nabokina SM, Lazo PA, Mollinedo F . Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1 . Journal of Leukocyte Biology . 65 . 3 . 397–406 . Mar 1999 . 10080545 . 10.1002/jlb.65.3.397. 10261/59829 . 18988377 . free .
• Roperch JP, Lethrone F, Prieur S, Piouffre L, Israeli D, Tuynder M, Nemani M, Pasturaud P, Gendron MC, Dausset J, Oren M, Amson RB, Telerman A . SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21(Waf1) . Proceedings of the National Academy of Sciences of the United States of America . 96 . 14 . 8070–3 . Jul 1999 . 10393949 . 22189 . 10.1073/pnas.96.14.8070 . 1999PNAS...96.8070R . free .
• zur Stadt U, Schmidt S, Kasper B, Beutel K, Diler AS, Henter JI, Kabisch H, Schneppenheim R, Nürnberg P, Janka G, Hennies HC . Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11 . Human Molecular Genetics . 14 . 6 . 827–34 . Mar 2005 . 15703195 . 10.1093/hmg/ddi076 . free .
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein–protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . Sep 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
• Yamamoto K, Ishii E, Horiuchi H, Ueda I, Ohga S, Nishi M, Ogata Y, Zaitsu M, Morimoto A, Hara T, Imashuku S, Sasazuki T, Yasukawa M . Mutations of syntaxin 11 and SNAP23 genes as causes of familial hemophagocytic lymphohistiocytosis were not found in Japanese people . Journal of Human Genetics . 50 . 11 . 600–3 . 2006 . 16180048 . 10.1007/s10038-005-0293-1 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein–protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Zur Stadt U, Beutel K, Kolberg S, Schneppenheim R, Kabisch H, Janka G, Hennies HC . Mutation spectrum in children with primary hemophagocytic lymphohistiocytosis: molecular and functional analyses of PRF1, UNC13D, STX11, and RAB27A . Human Mutation . 27 . 1 . 62–8 . Jan 2006 . 16278825 . 10.1002/humu.20274 . 19226893 . free .
• Bryceson YT, Rudd E, Zheng C, Edner J, Ma D, Wood SM, Bechensteen AG, Boelens JJ, Celkan T, Farah RA, Hultenby K, Winiarski J, Roche PA, Nordenskjöld M, Henter JI, Long EO, Ljunggren HG . Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients . Blood . 110 . 6 . 1906–15 . Sep 2007 . 17525286 . 1976360 . 10.1182/blood-2007-02-074468 .
• Arneson LN, Brickshawana A, Segovis CM, Schoon RA, Dick CJ, Leibson PJ . Cutting edge: syntaxin 11 regulates lymphocyte-mediated secretion and cytotoxicity . Journal of Immunology . 179 . 6 . 3397–401 . Sep 2007 . 17785771 . 10.4049/jimmunol.179.6.3397 . free .

Notes and References

1. Web site: Entrez Gene: STX11 syntaxin 11.
2. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Huda Zoghbi. Towards a proteome-scale map of the human protein–protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R. 4427026.
3. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein–protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . Sep 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
4. Valdez AC, Cabaniols JP, Brown MJ, Roche PA . Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network . Journal of Cell Science . 112 . 6 . 845–54 . Mar 1999 . 10.1242/jcs.112.6.845 . 10036234 .