STT3B explained

Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit STT3B is an enzyme that in humans is encoded by the STT3B gene.^{[1] [2] [3]}

Function

The STT3B protein contains a highly immunogenic minor histocompatibility antigen epitope of 9 amino acids, B6(dom1). Like ITM1 (MIM 601134), STT3B is homologous to yeast STT3, an oligosaccharyltransferase essential for cell proliferation.^[4]

See also

• Oligosaccharyltransferase

Further reading

• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . November 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T . 6 . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries . DNA Research . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .
• Shibatani T, David LL, McCormack AL, Frueh K, Skach WR . Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits . Biochemistry . 44 . 16 . 5982–92 . April 2005 . 15835887 . 10.1021/bi047328f .

Notes and References

1. Kelleher DJ, Karaoglu D, Mandon EC, Gilmore R . Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties . Molecular Cell . 12 . 1 . 101–11 . July 2003 . 12887896 . 10.1016/S1097-2765(03)00243-0 . free .
2. McBride K, Baron C, Picard S, Martin S, Boismenu D, Bell A, Bergeron J, Perreault C . 6 . The model B6(dom1) minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene . Immunogenetics . 54 . 8 . 562–9 . November 2002 . 12439619 . 10.1007/s00251-002-0502-4 . 25068432 .
3. Web site: Entrez Gene: STT3B STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae).
4. McBride K, Baron C, Picard S, Martin S, Boismenu D, Bell A, Bergeron J, Perreault C . 6 . The model B6(dom1) minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene . Immunogenetics . 54 . 8 . 562–9 . November 2002 . 12439619 . 10.1007/s00251-002-0502-4 . Springer Science and Business Media LLC . 25068432 .