STMN3 explained

Stathmin-3 is a protein that in humans is encoded by the STMN3 gene.^{[1] [2] [3]}

Function

The protein encoded by this gene belongs to the stathmin/oncoprotein 18 family of microtubule-destabilizing phosphoproteins. It is similar to the SCG10 protein and is involved in signal transduction and regulation of microtubule dynamics.^[4]

Interactions

STMN3 has been shown to interact with TRPC5.^[5]

Further reading

• Gavet O, Ozon S, Manceau V, Lawler S, Curmi P, Sobel A . The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network . Journal of Cell Science . 111 (Pt 22) . 22 . 3333–46 . November 1998 . 10.1242/jcs.111.22.3333 . 9788875 .
• Charbaut E, Curmi PA, Ozon S, Lachkar S, Redeker V, Sobel A . Stathmin family proteins display specific molecular and tubulin binding properties . The Journal of Biological Chemistry . 276 . 19 . 16146–54 . May 2001 . 11278715 . 10.1074/jbc.M010637200 . free .
• Bièche I, Maucuer A, Laurendeau I, Lachkar S, Spano AJ, Frankfurter A, Lévy P, Manceau V, Sobel A, Vidaud M, Curmi PA . Expression of stathmin family genes in human tissues: non-neural-restricted expression for SCLIP . Genomics . 81 . 4 . 400–10 . April 2003 . 12676564 . 10.1016/S0888-7543(03)00031-4 .
• Greka A, Navarro B, Oancea E, Duggan A, Clapham DE . TRPC5 is a regulator of hippocampal neurite length and growth cone morphology . Nature Neuroscience . 6 . 8 . 837–45 . August 2003 . 12858178 . 10.1038/nn1092 . 7523946 .

Notes and References

1. Ozon S, Byk T, Sobel A . SCLIP: a novel SCG10-like protein of the stathmin family expressed in the nervous system . Journal of Neurochemistry . 70 . 6 . 2386–96 . June 1998 . 9603203 . 10.1046/j.1471-4159.1998.70062386.x . 1252160 .
2. Bai C, Connolly B, Metzker ML, Hilliard CA, Liu X, Sandig V, Soderman A, Galloway SM, Liu Q, Austin CP, Caskey CT . Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster . Proceedings of the National Academy of Sciences of the United States of America . 97 . 3 . 1230–5 . February 2000 . 10655513 . 15578 . 10.1073/pnas.97.3.1230 . 2000PNAS...97.1230B . free .
3. Web site: Entrez Gene: STMN3 stathmin-like 3.
4. Web site: Entrez Gene: STMN3 stathmin-like 3.
5. Greka A, Navarro B, Oancea E, Duggan A, Clapham DE . TRPC5 is a regulator of hippocampal neurite length and growth cone morphology . Nature Neuroscience . 6 . 8 . 837–45 . August 2003 . 12858178 . 10.1038/nn1092 . 7523946 .