STMN2 explained

Stathmin-2 is a protein that in humans is encoded by the STMN2 gene.^{[1] [2] [3]}

Function

Superior cervical ganglion-10 is a neuronal growth-associated protein which shares significant amino acid sequence similarity with the phosphoprotein stathmin (MIM 151442).[supplied by OMIM]^[3]

Interactions

STMN2 has been shown to interact with RGS6.

Further reading

• Di Paolo G, Lutjens R, Pellier V, Stimpson SA, Beuchat MH, Catsicas S, Grenningloh G . Targeting of SCG10 to the area of the Golgi complex is mediated by its NH2-terminal region . The Journal of Biological Chemistry . 272 . 8 . 5175–82 . February 1997 . 9030585 . 10.1074/jbc.272.8.5175 . free .
• Antonsson B, Lütjens R, Di Paolo G, Kassel D, Allet B, Bernard A, Catsicas S, Grenningloh G . Purification, characterization, and in vitro phosphorylation of the neuron-specific membrane-associated protein SCG10 . Protein Expression and Purification . 9 . 3 . 363–71 . April 1997 . 9126608 . 10.1006/prep.1996.0710 .
• Antonsson B, Kassel DB, Di Paolo G, Lutjens R, Riederer BM, Grenningloh G . Identification of in vitro phosphorylation sites in the growth cone protein SCG10. Effect Of phosphorylation site mutants on microtubule-destabilizing activity . The Journal of Biological Chemistry . 273 . 14 . 8439–46 . April 1998 . 9525956 . 10.1074/jbc.273.14.8439 . free .
• Lutjens R, Igarashi M, Pellier V, Blasey H, Di Paolo G, Ruchti E, Pfulg C, Staple JK, Catsicas S, Grenningloh G . Localization and targeting of SCG10 to the trans-Golgi apparatus and growth cone vesicles . The European Journal of Neuroscience . 12 . 7 . 2224–34 . July 2000 . 10947801 . 10.1046/j.1460-9568.2000.00112.x . 41593815 .
• Neidhart S, Antonsson B, Gilliéron C, Vilbois F, Grenningloh G, Arkinstall S . c-Jun N-terminal kinase-3 (JNK3)/stress-activated protein kinase-beta (SAPKbeta) binds and phosphorylates the neuronal microtubule regulator SCG10 . FEBS Letters . 508 . 2 . 259–64 . November 2001 . 11718727 . 10.1016/S0014-5793(01)03090-3 . 84253949 .
• Nixon AB, Grenningloh G, Casey PJ . The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly . The Journal of Biological Chemistry . 277 . 20 . 18127–33 . May 2002 . 11882662 . 10.1074/jbc.M201065200 . free .
• Greka A, Navarro B, Oancea E, Duggan A, Clapham DE . TRPC5 is a regulator of hippocampal neurite length and growth cone morphology . Nature Neuroscience . 6 . 8 . 837–45 . August 2003 . 12858178 . 10.1038/nn1092 . 7523946 .
• Kuwabara T, Hsieh J, Nakashima K, Taira K, Gage FH . A small modulatory dsRNA specifies the fate of adult neural stem cells . Cell . 116 . 6 . 779–93 . March 2004 . 15035981 . 10.1016/S0092-8674(04)00248-X . 12656737 . free .
• Gocke CB, Yu H, Kang J . Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates . The Journal of Biological Chemistry . 280 . 6 . 5004–12 . February 2005 . 15561718 . 10.1074/jbc.M411718200 . free .
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . September 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Lee HS, Lee DC, Park MH, Yang SJ, Lee JJ, Kim DM, Jang Y, Lee JH, Choi JY, Kang YK, Kim DI, Park KC, Kim SY, Yoo HS, Choi EJ, Yeom YI . STMN2 is a novel target of beta-catenin/TCF-mediated transcription in human hepatoma cells . Biochemical and Biophysical Research Communications . 345 . 3 . 1059–67 . July 2006 . 16712787 . 10.1016/j.bbrc.2006.05.017 .
• Manna T, Grenningloh G, Miller HP, Wilson L . Stathmin family protein SCG10 differentially regulates the plus and minus end dynamics of microtubules at steady state in vitro: implications for its role in neurite outgrowth . Biochemistry . 46 . 11 . 3543–52 . March 2007 . 17311410 . 10.1021/bi061819d .

Notes and References

1. Okazaki T, Wang H, Masliah E, Cao M, Johnson SA, Sundsmo M, Saitoh T, Mori N . SCG10, a neuron-specific growth-associated protein in Alzheimer's disease . Neurobiology of Aging . 16 . 6 . 883–94 . June 1996 . 8622778 . 10.1016/0197-4580(95)02001-2 . 54320124 .
2. Liu Z, Chatterjee TK, Fisher RA . RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6 . The Journal of Biological Chemistry . 277 . 40 . 37832–9 . October 2002 . 12140291 . 10.1074/jbc.M205908200 . free .
3. Web site: Entrez Gene: STMN2 stathmin-like 2.