STK33 explained

Serine/threonine kinase 33 is a protein that in humans is encoded by the STK33 gene.

STK33 was identified as a synthetic lethal gene in KRAS-dependent cell lines.^[1]

STK33 has been considered as a target for reversible male contraceptives and the inhibitor CDD-2807 has been tested successfully in mice.^[2]

Notes and References

1. Book: Spoonamore J, Weïwer M, Wei J, Guichard B, Ross NT, Masson K, Silkworth W, Dandapani S, Munoz B, Palmer M, Scherer C, Schreiber SL . Screen for Inhibitors of STK33 Kinase Activity . Probe Reports from the NIH Molecular Libraries Program [Internet]. . Bethesda (MD) . National Center for Biotechnology Information (US) . 23658944 . https://www.ncbi.nlm.nih.gov/books/NBK133418.
2. https://www.nih.gov/news-events/nih-research-matters/drug-causes-reversible-male-contraception-mice