STK19 explained

Serine/threonine-protein kinase 19 is an enzyme that in humans is encoded by the STK19 gene.^{[1] [2] [3]}

This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants.

See also

• RCCX

Further reading

• Yu CY . The complete exon-intron structure of a human complement component C4A gene. DNA sequences, polymorphism, and linkage to the 21-hydroxylase gene. . J. Immunol. . 146 . 3 . 1057–66 . 1991 . 10.4049/jimmunol.146.3.1057 . 1988494 .
• Shen L, Wu LC, Sanlioglu S, etal . Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication. . J. Biol. Chem. . 269 . 11 . 8466–76 . 1994 . 10.1016/S0021-9258(17)37217-4 . 8132574 . free .
• Ulgiati D, Townend DC, Christiansen FT, etal . Complete sequence of the complement C4 gene from the HLA-A1, B8, C4AQ0, C4B1, DR3 haplotype. . Immunogenetics . 43 . 4 . 250–2 . 1996 . 8575831 . 10.1007/BF00587313.
• Yang Z, Shen L, Dangel AW, etal . Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA. . Genomics . 53 . 3 . 338–47 . 1998 . 9799600 . 10.1006/geno.1998.5499 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6. . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . free .
• Xie T, Rowen L, Aguado B, etal . Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. . Genome Res. . 13 . 12 . 2621–36 . 2004 . 14656967 . 10.1101/gr.1736803 . 403804 .
• Lehner B, Semple JI, Brown SE, etal . Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. . Genomics . 83 . 1 . 153–67 . 2004 . 14667819 . 10.1016/S0888-7543(03)00235-0 .
• Wadle A, Mischo A, Henrich PP, etal . Characterization of Hap/BAG-1 variants as RP1 binding proteins with antiapoptotic activity. . Int. J. Cancer . 117 . 6 . 896–904 . 2005 . 15986447 . 10.1002/ijc.21259 . 36464436 .

Notes and References

1. Sargent CA, Anderson MJ, Hsieh SL, Kendall E, Gomez-Escobar N, Campbell RD . Characterisation of the novel gene G11 lying adjacent to the complement C4A gene in the human major histocompatibility complex . Hum Mol Genet . 3 . 3 . 481–8 . Jul 1994 . 8012361 . 10.1093/hmg/3.3.481 .
2. Gomez-Escobar N, Chou CF, Lin WW, Hsieh SL, Campbell RD . The G11 gene located in the major histocompatibility complex encodes a novel nuclear serine/threonine protein kinase . J Biol Chem . 273 . 47 . 30954–60 . Dec 1998 . 9812991 . 10.1074/jbc.273.47.30954 . free .
3. Web site: Entrez Gene: STK19 serine/threonine kinase 19.