STK17A explained

Serine/threonine kinase 17a is a protein that in humans is encoded by the STK17A gene.^[1]

Function

This gene is a member of the death-associated protein (DAP) kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity.

In a recent study the gene (among others) shows a major role in centenarians longer lifespan.^[2]

Further reading

• Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-Pérez L, Schiavi F, Leskelä S, Pita G, Milne R, Maravall J, Ramos I, Andía V, Rodríguez-Poyo P, Jara-Albarrán A, Meoro A, del Peso C, Arribas L, Iglesias P, Caballero J, Serrano J, Picó A, Pomares F, Giménez G, López-Mondéjar P, Castello R, Merante-Boschin I, Pelizzo MR, Mauricio D, Opocher G, Rodríguez-Antona C, González-Neira A, Matías-Guiu X, Santisteban P, Robledo M . 6 . The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors . PLOS Genetics . 5 . 9 . e1000637 . September 2009 . 19730683 . 2727793 . 10.1371/journal.pgen.1000637 . free .
• Sanjo H, Kawai T, Akira S . DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis . The Journal of Biological Chemistry . 273 . 44 . 29066–71 . October 1998 . 9786912 . 10.1074/jbc.273.44.29066 . free .
• Mao P, Hever MP, Niemaszyk LM, Haghkerdar JM, Yanco EG, Desai D, Beyrouthy MJ, Kerley-Hamilton JS, Freemantle SJ, Spinella MJ . 6 . Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells . The Journal of Biological Chemistry . 286 . 22 . 19381–91 . June 2011 . 21489989 . 3103316 . 10.1074/jbc.M111.218040 . free .

Notes and References

1. Web site: Entrez Gene: Serine/threonine kinase 17a .
2. Garagnani P, Marquis J, Delledonne M, Pirazzini C, Marasco E, Kwiatkowska KM, Iannuzzi V, Bacalini MG, Valsesia A, Carayol J, Raymond F, Ferrarini A, Xumerle L, Collino S, Mari D, Arosio B, Casati M, Ferri E, Monti D, Nacmias B, Sorbi S, Luiselli D, Pettener D, Castellani G, Sala C, Passarino G, De Rango F, D'Aquila P, Bertamini L, Martinelli N, Girelli D, Olivieri O, Giuliani C, Descombes P, Franceschi C . 6 . Whole-genome sequencing analysis of semi-supercentenarians . eLife . 10 . e57849 . May 2021 . 33941312 . 10.7554/eLife.57849 . 8096429 . Tyler JK, Suh Y, Shuldiner AR . free .