STH (gene) explained

Saitohin is a protein that in humans is encoded by the STH gene.^{[1] [2] [3]} This intronless gene encodes for 128 amino acids in an open reading frame. It is located in the human tau gene, in the intron between exons 9 and 10. Also, a single polymorphism of a nucleotide is seen through a change of glutamine residue 7(Q7R) to arginine.^[4] It is found to be susceptible to multiple degenerative diseases, however, the exact function of the gene is still unknown.^[5]

Further reading

• Adams MD, Kerlavage AR, Fleischmann RD, etal . Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. . Nature . 377 . 6547 Suppl . 3–174 . 1995 . 7566098 .
• Cook L, Brayne CE, Easton D, etal . No evidence for an association between Saitohin Q7R polymorphism and Alzheimer's disease. . Ann. Neurol. . 52 . 5 . 690–1 . 2002 . 12402275 . 10.1002/ana.10362 . 37700445 .
• Verpillat P, Ricard S, Hannequin D, etal . Is the saitohin gene involved in neurodegenerative diseases? . Ann. Neurol. . 52 . 6 . 829–32 . 2002 . 12447938 . 10.1002/ana.10384 . 35687241 .
• Zekanowski C, Pepłońska B, Styczyńska M, etal . Mutation screening of the MAPT and STH genes in Polish patients with clinically diagnosed frontotemporal dementia. . Dementia and Geriatric Cognitive Disorders . 16 . 3 . 126–31 . 2003 . 12826737 . 10.1159/000070999 . 24166927 .
• Combarros O, Rodero L, Infante J, etal . Age-dependent association between the Q7R polymorphism in the Saitohin gene and sporadic Alzheimer's disease. . Dementia and Geriatric Cognitive Disorders . 16 . 3 . 132–5 . 2003 . 12826738 . 10.1159/000071000 . 42452606 .
• de Silva R, Hope A, Pittman A, etal . Strong association of the Saitohin gene Q7 variant with progressive supranuclear palsy. . Neurology . 61 . 3 . 407–9 . 2004 . 12913211 . 10.1212/01.wnl.0000073140.25533.90. 38636041 .
• Pepłońska B, Zekanowski C, Religa D, etal . Strong association between Saitohin gene polymorphism and tau haplotype in the Polish population. . Neurosci. Lett. . 348 . 3 . 163–6 . 2003 . 12932819 . 10.1016/S0304-3940(03)00788-2 . 10736456 .
• Johansson A, Zetterberg H, Håkansson A, etal . TAU haplotype and the Saitohin Q7R gene polymorphism do not influence CSF Tau in Alzheimer's disease and are not associated with frontotemporal dementia or Parkinson's disease. . Neuro-Degenerative Diseases . 2 . 1 . 28–35 . 2006 . 16909000 . 10.1159/000086428 . 6644618 .

Notes and References

1. Conrad C, Vianna C, Freeman M, Davies P . A polymorphic gene nested within an intron of the tau gene: implications for Alzheimer's disease . Proc Natl Acad Sci U S A . 99 . 11 . 7751–6 . May 2002 . 12032355 . 124341 . 10.1073/pnas.112194599 . free . 2002PNAS...99.7751C .
2. Gao L, Tse SW, Conrad C, Andreadis A . Saitohin, which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative diseases, interacts with peroxiredoxin 6 . J Biol Chem . 280 . 47 . 39268–72 . Nov 2005 . 16186110 . 10.1074/jbc.M506116200 . free .
3. Web site: Entrez Gene: STH saitohin.
4. Conrad C, Vianna C, Freeman M, Davies P . May 2002 . A polymorphic gene nested within an intron of the tau gene: implications for Alzheimer's disease . Proc Natl Acad Sci U S A . 99 . 11 . 7751–6 . 10.1073/pnas.112194599 . 124341 . 12032355 . free. 2002PNAS...99.7751C .
5. Gao L, Tse SW, Conrad C, Andreadis A . Nov 2005 . Saitohin, which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative diseases, interacts with peroxiredoxin 6 . J Biol Chem . 280 . 47 . 39268–72 . 10.1074/jbc.M506116200 . 16186110 . free.