STEAP1 explained

Metalloreductase STEAP1 is an enzyme that in humans is encoded by the STEAP1 gene.^[1]

This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions.^[1]

Further reading

• Toward a complete human genome sequence. . Genome Res. . 8 . 11 . 1097–108 . 1999 . 9847074 . 10.1101/gr.8.11.1097. free . Sanger Centre . The . Washington University Genome Sequencing Cente . The .
• Hubert RS, Vivanco I, Chen E, etal . STEAP: A prostate-specific cell-surface antigen highly expressed in human prostate tumors . Proc. Natl. Acad. Sci. U.S.A. . 96 . 25 . 14523–8 . 2000 . 10588738 . 10.1073/pnas.96.25.14523 . 24469 . free .
• Yang D, Holt GE, Velders MP, etal . Murine six-transmembrane epithelial antigen of the prostate, prostate stem cell antigen, and prostate-specific membrane antigen: prostate-specific cell-surface antigens highly expressed in prostate cancer of transgenic adenocarcinoma mouse prostate mice . Cancer Res. . 61 . 15 . 5857–60 . 2001 . 11479226 .
• Korkmaz KS, Elbi C, Korkmaz CG, etal . Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer . J. Biol. Chem. . 277 . 39 . 36689–96 . 2002 . 12095985 . 10.1074/jbc.M202414200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Scherer SW, Cheung J, MacDonald JR, etal . Human Chromosome 7: DNA Sequence and Biology . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 10.1126/science.1083423 . 2882961 . 2003Sci...300..767S .
• Hillier LW, Fulton RS, Fulton LA, etal . The DNA sequence of human chromosome 7 . Nature . 424 . 6945 . 157–64 . 2003 . 12853948 . 10.1038/nature01782 . 2003Natur.424..157H . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rodeberg DA, Nuss RA, Elsawa SF, Celis E . Recognition of Six-Transmembrane Epithelial Antigen of the Prostate–Expressing Tumor Cells by Peptide Antigen–Induced Cytotoxic T Lymphocytes . Clin. Cancer Res. . 11 . 12 . 4545–52 . 2005 . 15958640 . 10.1158/1078-0432.CCR-04-2235 . 1698136 .

Notes and References

1. Web site: Entrez Gene: STEAP1 six transmembrane epithelial antigen of the prostate 1.