STAT5B explained

Signal transducer and activator of transcription 5B is a protein that in humans is encoded by the STAT5B gene.^[1] STAT5B orthologs^[2] have been identified in most placentals for which complete genome data are available.

Function

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APML). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APML.^[3]

Interactions

STAT5B has been shown to interact with:

• Glucocorticoid receptor,^[4]
• Janus kinase 1,
• Janus kinase 2,^{[5] [6]} and
• PTPN11.^[7]

See also

• STAT5

Further reading

• Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW . Signaling through the JAK/STAT pathway, recent advances and future challenges . Gene . 285 . 1–2 . 1–24 . 2002 . 12039028 . 10.1016/S0378-1119(02)00398-0 .

Notes and References

1. Lin JX, Mietz J, Modi WS, John S, Leonard WJ . Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells . J. Biol. Chem. . 271 . 18 . 10738–44 . July 1996 . 8631883 . 10.1074/jbc.271.18.10738 . free .
2. Web site: OrthoMaM phylogenetic marker: STAT5B coding sequence . 2010-02-17 . 2015-09-24 . https://web.archive.org/web/20150924061943/http://www.orthomam.univ-montp2.fr/orthomam/data/cds/detailMarkers/ENSG00000173757_STAT5B.xml . dead .
3. Web site: Entrez Gene: STAT5B signal transducer and activator of transcription 5B.
4. Stöcklin E, Wissler M, Gouilleux F, Groner B . Functional interactions between Stat5 and the glucocorticoid receptor . Nature . 383 . 6602 . 726–8 . October 1996 . 8878484 . 10.1038/383726a0 . 1996Natur.383..726S . 4356272 .
5. Fujitani Y, Hibi M, Fukada T, Takahashi-Tezuka M, Yoshida H, Yamaguchi T, Sugiyama K, Yamanaka Y, Nakajima K, Hirano T . An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT . Oncogene . 14 . 7 . 751–61 . February 1997 . 9047382 . 10.1038/sj.onc.1200907 . 20789082 .
6. Barahmand-Pour F, Meinke A, Groner B, Decker T . Jak2-Stat5 interactions analyzed in yeast . J. Biol. Chem. . 273 . 20 . 12567–75 . May 1998 . 9575217 . 10.1074/jbc.273.20.12567. free .
7. Yu CL, Jin YJ, Burakoff SJ . Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation . J. Biol. Chem. . 275 . 1 . 599–604 . January 2000 . 10617656 . 10.1074/jbc.275.1.599. free .