STAMBP explained

STAM-binding protein is a protein that in humans is encoded by the STAMBP gene.^{[1] [2]}

Function

Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

Mutations in this gene have been associated to cases of microcephaly (doi:10.1038/ng.2602)

Interactions

STAMBP has been shown to interact with RNF11,^[3] Signal transducing adaptor molecule^[4] and GRAP2.^{[5] [6]}

Further reading

• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Analytical Biochemistry . 236 . 1 . 107–13 . April 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA . Large-scale concatenation cDNA sequencing . Genome Research . 7 . 4 . 353–8 . April 1997 . 9110174 . 139146 . 10.1101/gr.7.4.353 .
• Asada H, Ishii N, Sasaki Y, Endo K, Kasai H, Tanaka N, Takeshita T, Tsuchiya S, Konno T, Sugamura K . Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT . The Journal of Experimental Medicine . 189 . 9 . 1383–90 . May 1999 . 10224278 . 2193052 . 10.1084/jem.189.9.1383 .
• Endo K, Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, Kikuchi K, Yamada M, Chenb M, O'Shea JJ, Sugamura K . STAM2, a new member of the STAM family, binding to the Janus kinases . FEBS Letters . 477 . 1–2 . 55–61 . July 2000 . 10899310 . 10.1016/S0014-5793(00)01760-9 . 31811757 .
• Itoh F, Asao H, Sugamura K, Heldin CH, ten Dijke P, Itoh S . Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads . The EMBO Journal . 20 . 15 . 4132–42 . August 2001 . 11483516 . 149146 . 10.1093/emboj/20.15.4132 .
• Ishii N, Owada Y, Yamada M, Miura S, Murata K, Asao H, Kondo H, Sugamura K . Loss of neurons in the hippocampus and cerebral cortex of AMSH-deficient mice . Molecular and Cellular Biology . 21 . 24 . 8626–37 . December 2001 . 11713295 . 100023 . 10.1128/MCB.21.24.8626-8637.2001 .
• Maytal-Kivity V, Reis N, Hofmann K, Glickman MH . MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function . BMC Biochemistry . 3 . 28 . 2006 . 12370088 . 129983 . 10.1186/1471-2091-3-28 . free .
• Ibarrola N, Kratchmarova I, Nakajima D, Schiemann WP, Moustakas A, Pandey A, Mann M . Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling . BMC Cell Biology . 5 . 2 . January 2004 . 14728725 . 385422 . 10.1186/1471-2121-5-2 . free .
• Ambroggio XI, Rees DC, Deshaies RJ . JAMM: a metalloprotease-like zinc site in the proteasome and signalosome . PLOS Biology . 2 . 1 . E2 . January 2004 . 14737182 . 300881 . 10.1371/journal.pbio.0020002 . free .
• Li H, Seth A . An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein . Oncogene . 23 . 10 . 1801–8 . March 2004 . 14755250 . 10.1038/sj.onc.1207319 . 37253372 .
• McCullough J, Clague MJ, Urbé S . AMSH is an endosome-associated ubiquitin isopeptidase . The Journal of Cell Biology . 166 . 4 . 487–92 . August 2004 . 15314065 . 2172215 . 10.1083/jcb.200401141 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Row PE, Prior IA, McCullough J, Clague MJ, Urbé S . The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation . The Journal of Biological Chemistry . 281 . 18 . 12618–24 . May 2006 . 16520378 . 10.1074/jbc.M512615200 . free .
• Nakamura M, Tanaka N, Kitamura N, Komada M . Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes . Genes to Cells . 11 . 6 . 593–606 . June 2006 . 16716190 . 10.1111/j.1365-2443.2006.00963.x . 30077507 .
• Tsang HT, Connell JW, Brown SE, Thompson A, Reid E, Sanderson CM . A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex . Genomics . 88 . 3 . 333–46 . September 2006 . 16730941 . 10.1016/j.ygeno.2006.04.003 .

Notes and References

1. Tanaka N, Kaneko K, Asao H, Kasai H, Endo Y, Fujita T, Takeshita T, Sugamura K . Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines . The Journal of Biological Chemistry . 274 . 27 . 19129–35 . July 1999 . 10383417 . 10.1074/jbc.274.27.19129 . free .
2. Web site: Entrez Gene: STAMBP STAM binding protein.
3. Li H, Seth A . An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein . Oncogene . 23 . 10 . 1801–8 . March 2004 . 14755250 . 10.1038/sj.onc.1207319 . 37253372 .
4. Kato M, Miyazawa K, Kitamura N . A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP . The Journal of Biological Chemistry . 275 . 48 . 37481–7 . December 2000 . 10982817 . 10.1074/jbc.M007251200 . free .
5. Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
6. Asada H, Ishii N, Sasaki Y, Endo K, Kasai H, Tanaka N, Takeshita T, Tsuchiya S, Konno T, Sugamura K . Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT . The Journal of Experimental Medicine . 189 . 9 . 1383–90 . May 1999 . 10224278 . 2193052 . 10.1084/jem.189.9.1383 .