STAB1 explained

Stabilin-1 is a protein that in humans is encoded by the STAB1 gene.^{[1] [2] [3]}

This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes.^[4] STAB1 is also known to interact with the protein chitinase domain-containing protein 1.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, etal . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . free .
• Lalor PF, Lai WK, Curbishley SM, etal . Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo. . World J. Gastroenterol. . 12 . 34 . 5429–39 . 2006 . 17006978 . 10.3748/wjg.v12.i34.5429. 4088223 . free .
• Nagase T, Seki N, Ishikawa K, etal . Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. . DNA Res. . 3 . 5 . 321–9, 341–54 . 1997 . 9039502 . 10.1093/dnares/3.5.321 . free .
• Dias Neto E, Correa RG, Verjovski-Almeida S, etal . Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 7 . 3491–6 . 2000 . 10737800 . 10.1073/pnas.97.7.3491 . 16267 . 2000PNAS...97.3491D . free .
• Tamura Y, Adachi H, Osuga J, etal . FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products. . J. Biol. Chem. . 278 . 15 . 12613–7 . 2003 . 12473645 . 10.1074/jbc.M210211200 . free .
• Irjala H, Elima K, Johansson EL, etal . The same endothelial receptor controls lymphocyte traffic both in vascular and lymphatic vessels. . Eur. J. Immunol. . 33 . 3 . 815–24 . 2003 . 12616502 . 10.1002/eji.200323859 . 5819351 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Salmi M, Koskinen K, Henttinen T, etal . CLEVER-1 mediates lymphocyte transmigration through vascular and lymphatic endothelium. . Blood . 104 . 13 . 3849–57 . 2005 . 15297319 . 10.1182/blood-2004-01-0222 . 9952957 .
• Prevo R, Banerji S, Ni J, Jackson DG . Rapid plasma membrane-endosomal trafficking of the lymph node sinus and high endothelial venule scavenger receptor/homing receptor stabilin-1 (FEEL-1/CLEVER-1). . J. Biol. Chem. . 279 . 50 . 52580–92 . 2005 . 15345716 . 10.1074/jbc.M406897200 . free .
• Kzhyshkowska J, Gratchev A, Martens JH, etal . Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors. . J. Leukoc. Biol. . 76 . 6 . 1151–61 . 2005 . 15345724 . 10.1189/jlb.0504300 . 20040432 .
• Hansen B, Longati P, Elvevold K, etal . Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding. . Exp. Cell Res. . 303 . 1 . 160–73 . 2005 . 15572036 . 10.1016/j.yexcr.2004.09.017 .
• Kzhyshkowska J, Mamidi S, Gratchev A, etal . Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway. . Blood . 107 . 8 . 3221–8 . 2006 . 16357325 . 10.1182/blood-2005-07-2843 . free .
• Kzhyshkowska J, Workman G, Cardó-Vila M, etal . Novel function of alternatively activated macrophages: stabilin-1-mediated clearance of SPARC. . J. Immunol. . 176 . 10 . 5825–32 . 2006 . 16670288 . 10.4049/jimmunol.176.10.5825. free .

Notes and References

1. Politz O, Gratchev A, McCourt PA, Schledzewski K, Guillot P, Johansson S, Svineng G, Franke P, Kannicht C, Kzhyshkowska J, Longati P, Velten FW, Johansson S, Goerdt S . Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues . Biochem J . 362 . Pt 1 . 155–64 . Feb 2002 . 11829752 . 1222372 . 10.1042/0264-6021:3620155 .
2. Adachi H, Tsujimoto M . FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities . J Biol Chem . 277 . 37 . 34264–70 . Sep 2002 . 12077138 . 10.1074/jbc.M204277200 . free .
3. Web site: Entrez Gene: STAB1 stabilin 1.
4. Web site: Entrez Gene: STAB1 stabilin 1.