ST8SIA2 explained

Alpha-2,8-sialyltransferase 8B is an enzyme that in humans is encoded by the ST8SIA2 gene.^{[1] [2]}

Function

The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29.

Further reading

• Munro S . An investigation of the role of transmembrane domains in Golgi protein retention . The EMBO Journal . 14 . 19 . 4695–704 . October 1995 . 7588599 . 394566 . 10.1002/j.1460-2075.1995.tb00151.x.
• Kitagawa H, Paulson JC . Differential expression of five sialyltransferase genes in human tissues . The Journal of Biological Chemistry . 269 . 27 . 17872–8 . July 1994 . 10.1016/S0021-9258(17)32390-6 . 8027041 . free .
• Kojima N, Tachida Y, Yoshida Y, Tsuji S . Characterization of mouse ST8Sia II (STX) as a neural cell adhesion molecule-specific polysialic acid synthase. Requirement of core alpha1,6-linked fucose and a polypeptide chain for polysialylation . The Journal of Biological Chemistry . 271 . 32 . 19457–63 . August 1996 . 8702635 . 10.1074/jbc.271.32.19457 . free.
• Angata K, Nakayama J, Fredette B, Chong K, Ranscht B, Fukuda M . Human STX polysialyltransferase forms the embryonic form of the neural cell adhesion molecule. Tissue-specific expression, neurite outgrowth, and chromosomal localization in comparison with another polysialyltransferase, PST . The Journal of Biological Chemistry . 272 . 11 . 7182–90 . March 1997 . 9054414 . 10.1074/jbc.272.11.7182 . free .
• Close BE, Colley KJ . In vivo autopolysialylation and localization of the polysialyltransferases PST and STX . The Journal of Biological Chemistry . 273 . 51 . 34586–93 . December 1998 . 9852130 . 10.1074/jbc.273.51.34586 . free .
• Angata K, Suzuki M, McAuliffe J, Ding Y, Hindsgaul O, Fukuda M . Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III . The Journal of Biological Chemistry . 275 . 24 . 18594–601 . June 2000 . 10766765 . 10.1074/jbc.M910204199 . free .
• Close BE, Wilkinson JM, Bohrer TJ, Goodwin CP, Broom LJ, Colley KJ . The polysialyltransferase ST8Sia II/STX: posttranslational processing and role of autopolysialylation in the polysialylation of neural cell adhesion molecule . Glycobiology . 11 . 11 . 997–1008 . November 2001 . 11744634 . 10.1093/glycob/11.11.997 .
• Angata K, Suzuki M, Fukuda M . ST8Sia II and ST8Sia IV polysialyltransferases exhibit marked differences in utilizing various acceptors containing oligosialic acid and short polysialic acid. The basis for cooperative polysialylation by two enzymes . The Journal of Biological Chemistry . 277 . 39 . 36808–17 . September 2002 . 12138100 . 10.1074/jbc.M204632200 . free .
• Lazzell DR, Belizaire R, Thakur P, Sherry DM, Janz R . SV2B regulates synaptotagmin 1 by direct interaction . The Journal of Biological Chemistry . 279 . 50 . 52124–31 . December 2004 . 15466855 . 10.1074/jbc.M407502200 . free .
• Beecken WD, Engl T, Ogbomo H, Relja B, Cinatl J, Bereiter-Hahn J, Oppermann E, Jonas D, Blaheta RA . Valproic acid modulates NCAM polysialylation and polysialyltransferase mRNA expression in human tumor cells . International Immunopharmacology . 5 . 4 . 757–69 . April 2005 . 15710344 . 10.1016/j.intimp.2004.12.009 .
• Arai M, Yamada K, Toyota T, Obata N, Haga S, Yoshida Y, Nakamura K, Minabe Y, Ujike H, Sora I, Ikeda K, Mori N, Yoshikawa T, Itokawa M . Association between polymorphisms in the promoter region of the sialyltransferase 8B (SIAT8B) gene and schizophrenia . Biological Psychiatry . 59 . 7 . 652–9 . April 2006 . 16229822 . 10.1016/j.biopsych.2005.08.016 . 349683 .
• Szabo R, Skropeta D, etal . Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities. . Med. Res. Rev. . 37 . 2 . 210–270 . 2017 . 10.1002/med.21407 . 27678392. 26280291 .

Notes and References

1. Scheidegger EP, Sternberg LR, Roth J, Lowe JB . A human STX cDNA confers polysialic acid expression in mammalian cells . The Journal of Biological Chemistry . 270 . 39 . 22685–8 . September 1995 . 7559389 . 10.1074/jbc.270.39.22685 . free.
2. Web site: Entrez Gene: ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2.