St6 beta-galactoside alpha-2,6-sialyltransferase 2 explained
ST6 beta-galactoside alpha-2,6-sialyltransferase 2 is a protein that in humans is encoded by the ST6GAL2 gene.[1]
Function
This locus encodes a sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in risperidone response in schizophrenic patients. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012].
Further reading
- Krzewinski-Recchi MA, Julien S, Juliant S, Teintenier-Lelièvre M, Samyn-Petit B, Montiel MD, Mir AM, Cerutti M, Harduin-Lepers A, Delannoy P . Identification and functional expression of a second human beta-galactoside alpha2,6-sialyltransferase, ST6Gal II . Eur. J. Biochem. . 270 . 5 . 950–61 . March 2003 . 12603328 . 10.1046/j.1432-1033.2003.03458.x. free .
- Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C . Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling . Gut . 58 . 8 . 1078–83 . August 2009 . 19240061 . 10.1136/gut.2008.169052 . 17111427 .
- Lehoux S, Groux-Degroote S, Cazet A, Dhaenens CM, Maurage CA, Caillet-Boudin ML, Delannoy P, Krzewinski-Recchi MA . Transcriptional regulation of the human ST6GAL2 gene in cerebral cortex and neuronal cells . Glycoconj. J. . 27 . 1 . 99–114 . January 2010 . 19768537 . 10.1007/s10719-009-9260-y . 21921351 .
- Ikeda M, Tomita Y, Mouri A, Koga M, Okochi T, Yoshimura R, Yamanouchi Y, Kinoshita Y, Hashimoto R, Williams HJ, Takeda M, Nakamura J, Nabeshima T, Owen MJ, O'Donovan MC, Honda H, Arinami T, Ozaki N, Iwata N . Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches . Biol. Psychiatry . 67 . 3 . 263–9 . February 2010 . 19850283 . 10.1016/j.biopsych.2009.08.030 . 25280425 .
- Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Mol. Med. . 16 . 7–8 . 247–53 . 2010 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
Notes and References
- Web site: Entrez Gene: ST6 beta-galactoside alpha-2,6-sialyltransferase 2. 2018-08-23.
