SSH3 explained
Protein phosphatase Slingshot homolog 3 is an enzyme that in humans is encoded by the SSH3 gene.[1] [2]
Function
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM][3]
Further reading
- Kligys K, Claiborne JN, DeBiase PJ, Hopkinson SB, Wu Y, Mizuno K, Jones JC . The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes . The Journal of Biological Chemistry . 282 . 44 . 32520–8 . November 2007 . 17848544 . 2754063 . 10.1074/jbc.M707041200 . free .
- Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nature Biotechnology . 24 . 10 . 1285–92 . October 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
- Soosairajah J, Maiti S, Wiggan O, Sarmiere P, Moussi N, Sarcevic B, Sampath R, Bamburg JR, Bernard O . Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin . The EMBO Journal . 24 . 3 . 473–86 . February 2005 . 15660133 . 548651 . 10.1038/sj.emboj.7600543 .
- Ohta Y, Kousaka K, Nagata-Ohashi K, Ohashi K, Muramoto A, Shima Y, Niwa R, Uemura T, Mizuno K . Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin . Genes to Cells . 8 . 10 . 811–24 . October 2003 . 14531860 . 10.1046/j.1365-2443.2003.00678.x . 24247372 .
Notes and References
- Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T . Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin . Cell . 108 . 2 . 233–46 . January 2002 . 11832213 . 10.1016/S0092-8674(01)00638-9 . 5576208 . free .
- Web site: Entrez Gene: SSH3 slingshot homolog 3 (Drosophila).
- Web site: Entrez Gene: SSH3 slingshot homolog 3 (Drosophila).
